Biology:POM121

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Nuclear envelope pore membrane protein POM 121 is a protein that in humans is encoded by the POM121 gene.[1][2][3] Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.[4]

Function

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope.[4]

Antibodies against this protein can be used to identify the nuclear envelope in immunofluorescence experiments.[5]

References

  1. "An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region". J Cell Biol 122 (3): 513–21. Aug 1993. doi:10.1083/jcb.122.3.513. PMID 8335683. 
  2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. Dec 1998. doi:10.1093/dnares/5.3.169. PMID 9734811. 
  3. "Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes". FEBS Lett 581 (25): 4910–6. Oct 2007. doi:10.1016/j.febslet.2007.09.021. PMID 17900573. 
  4. 4.0 4.1 "Entrez Gene: POM121 POM121 membrane glycoprotein (homo sapiens)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9883. 
  5. "Sequential degradation of proteins from the nuclear envelope during apoptosis". J. Cell Sci. 114 (Pt 20): 3643–53. October 2001. doi:10.1242/jcs.114.20.3643. PMID 11707516. 

Further reading