Biology:PPIL1
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Peptidyl-prolyl cis-trans isomerase-like 1 is an enzyme that in humans is encoded by the PPIL1 gene.[1][2][3]
This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions.
Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.[3]
References
- ↑ "Reassignment of peptidyl prolyl isomerase-like 1 gene (PPIL1) to human chromosome region 6p21.1 by radiation hybrid mapping and fluorescence in situ hybridization". Cytogenet Cell Genet 83 (3–4): 228–9. Mar 1999. doi:10.1159/000015186. PMID 10072585.
- ↑ "Cloning, expression and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain". Cytogenet Cell Genet 72 (2–3): 242–5. Jan 1997. doi:10.1159/000134199. PMID 8978786.
- ↑ 3.0 3.1 "Entrez Gene: PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51645.
Further reading
- "Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex.". Genome Res. 8 (6): 631–43. 1999. doi:10.1101/gr.8.6.631. PMID 9647638.
- "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. 2000. doi:10.1101/gr.10.5.703. PMID 10810093.
- "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA 8 (4): 426–39. 2002. doi:10.1017/S1355838202021088. PMID 11991638.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. 2003. doi:10.1038/nature02055. PMID 14574404.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Backbone and side chain assignments of human Peptidylprolyl Isomerase Like 1 (hPPIL1).". J. Biomol. NMR 31 (2): 179–80. 2005. doi:10.1007/s10858-004-8238-0. PMID 15772761.
- "Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP.". J. Biol. Chem. 281 (23): 15900–8. 2006. doi:10.1074/jbc.M511155200. PMID 16595688.
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