Biology:PPP1R13B
From HandWiki
 Generic protein structure example |
Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene.[1][2]
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.[2]
References
- ↑ "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (5): 277–86. Apr 1999. doi:10.1093/dnares/5.5.277. PMID 9872452.
- ↑ 2.0 2.1 "Entrez Gene: PPP1R13B protein phosphatase 1, regulatory (inhibitor) subunit 13B". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23368.
Further reading
- "ASPP--Apoptotic specific regulator of p53.". Biochim. Biophys. Acta 1756 (1): 77–80. 2005. doi:10.1016/j.bbcan.2005.08.002. PMID 16139958.
- "ASPP proteins specifically stimulate the apoptotic function of p53.". Mol. Cell 8 (4): 781–94. 2001. doi:10.1016/S1097-2765(01)00367-7. PMID 11684014.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. 2003. doi:10.1038/nature01348. PMID 12508121. Bibcode: 2003Natur.421..601H.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "ASPP1 and ASPP2: common activators of p53 family members.". Mol. Cell. Biol. 24 (3): 1341–50. 2004. doi:10.1128/MCB.24.3.1341-1350.2004. PMID 14729977.
- "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F.". Cell Death Differ. 12 (4): 377–83. 2005. doi:10.1038/sj.cdd.4401575. PMID 15706352.
- "ASPP1 and ASPP2 are new transcriptional targets of E2F.". Cell Death Differ. 12 (4): 369–76. 2005. doi:10.1038/sj.cdd.4401562. PMID 15731768.
- "Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53.". FEBS Lett. 579 (7): 1587–90. 2005. doi:10.1016/j.febslet.2005.01.069. PMID 15757645.
- "Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation.". Oncogene 24 (23): 3836–41. 2005. doi:10.1038/sj.onc.1208535. PMID 15782125.
- "ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia.". Oncogene 25 (13): 1862–70. 2006. doi:10.1038/sj.onc.1209236. PMID 16314841. http://dadun.unav.edu/bitstream/10171/18354/1/2006_Oncogene_Agirre_ASPP1%2c%20a%20common%20activator%20of%20TP53%2c%20is%20inactivated%20by%20aberrant%20methylation%20of%20its%20promoter%20in%20Acute%20Lymphoblastic%20Leukemia.pdf.
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