Biology:PPP6C

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Serine/threonine-protein phosphatase 6 catalytic subunit is an enzyme that in humans is encoded by the PPP6C gene.[1][2]


Interactions

PPP6C has been shown to interact with IGBP1.[3][4]

References

  1. ↑ "Localization of the novel serine/threonine protein phosphatase 6 gene (PPP6C) to human chromosome Xq22.3". Genomics 41 (2): 296–7. April 1997. doi:10.1006/geno.1997.4640. PMID 9143513. 
  2. ↑ "Entrez Gene: PPP6C protein phosphatase 6, catalytic subunit". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5537. 
  3. ↑ "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics 4 (11): 1725–40. November 2005. doi:10.1074/mcp.M500231-MCP200. PMID 16085932. 
  4. ↑ "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications 247 (3): 827–32. June 1998. doi:10.1006/bbrc.1998.8792. PMID 9647778. 

Further reading

  • "The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation". Journal of Cell Science 109 ( Pt 12) (Pt 12): 2865–74. December 1996. doi:10.1242/jcs.109.12.2865. PMID 9013334. 
  • "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications 247 (3): 827–32. June 1998. doi:10.1006/bbrc.1998.8792. PMID 9647778. 
  • "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology 6 (2): 97–105. February 2004. doi:10.1038/ncb1086. PMID 14743216. 
  • "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. March 2005. doi:10.1126/science.1105776. PMID 15761153. Bibcode: 2005Sci...307.1621B. 
  • "Role of the Rho GTPase-activating protein RICS in neurite outgrowth". Genes to Cells 11 (6): 607–14. June 2006. doi:10.1111/j.1365-2443.2006.00966.x. PMID 16716191. 
  • "Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon". The Journal of Biological Chemistry 281 (32): 22624–34. August 2006. doi:10.1074/jbc.M601772200. PMID 16769727. 
  • "Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells". Cell Cycle 6 (11): 1386–92. June 2007. doi:10.4161/cc.6.11.4276. PMID 17568194. 





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