Biology:PRB4

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Basic salivary proline-rich protein 4 is a protein that in humans is encoded by the PRB4 gene.

The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.

PRB4 is post-translationally cleaved into three different mature peptides:

• Protein N1
• Glycosylated protein A
• Peptide P-D (also known as proline-rich peptide IB-5)

Further reading

• "Molecular Genetics of Human Salivary Proteins and Their Polymorphisms". Advances in Human Genetics 1. 17. 1988. pp. 141–199. doi:10.1007/978-1-4613-0987-1_5. ISBN 978-1-4612-8279-2. 
• Bennick A (1982). "Salivary proline-rich proteins". Mol. Cell. Biochem. 45 (2): 83–99. doi:10.1007/BF00223503. PMID 6810092. 
• "Length Polymorphisms in Human Proline-Rich Protein Genes Generated by Intragenic Unequal Crossing over". Genetics 120 (1): 267–78. 1989. doi:10.1093/genetics/120.1.267. PMID 2851479. 
• "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. Chem. 260 (20): 11123–30. 1985. doi:10.1016/S0021-9258(17)39156-1. PMID 2993301. 
• "Many Protein Products from a Few Loci: Assignment of Human Salivary Proline-Rich Proteins to Specific Loci". Genetics 120 (1): 255–65. 1989. doi:10.1093/genetics/120.1.255. PMID 3220251. 
• "Proline-rich proteins are present in serous cells of submucosal glands in the respiratory tract". Am. Rev. Respir. Dis. 130 (1): 115–8. 1984. doi:10.1164/arrd.1984.130.1.115. PMID 6377992. 
• "Complete amino acid sequence of a basic proline-rich peptide, P-D, from human parotid saliva". J. Biochem. 93 (2): 495–502. 1983. doi:10.1093/jb/93.3.883. PMID 6841349. 
• "Alignment of amino acid and DNA sequences of human proline-rich proteins". Crit. Rev. Oral Biol. Med. 4 (3–4): 287–92. 1993. doi:10.1177/10454411930040030501. PMID 8373986. 
• "The structure and evolution of the human salivary proline-rich protein gene family". Mamm. Genome 4 (1): 3–14. 1993. doi:10.1007/BF00364656. PMID 8422499. 
• "PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins". Am. J. Hum. Genet. 58 (1): 143–53. 1996. PMID 8554050. 
• "Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein". Mol. Biol. Cell 9 (3): 575–83. 1998. doi:10.1091/mbc.9.3.575. PMID 9487127. 
• "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases". Eur. J. Biochem. 268 (12): 3423–31. 2001. doi:10.1046/j.1432-1327.2001.02241.x. PMID 11422372. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Diagnostic value of ultrastructural nerve examination in Charcot-Marie-Tooth disease: two CMT 1B cases with pseudo-recessive inheritance". Acta Neuropathol. 113 (4): 443–9. 2007. doi:10.1007/s00401-007-0196-7. PMID 17294201.