Biology:PREX2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 is a protein that in humans is encoded by the PREX2 gene.[1][2]
Clinical relevance
Mutations in this gene have been recurrently seen in melanoma.[3]
References
- ↑ "Entrez Gene: Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2". https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=80243. Retrieved 2012-05-11.
- ↑ "P-REX2, a novel PI-3-kinase sensitive Rac exchange factor". FEBS Lett. 572 (1–3): 167–71. August 2004. doi:10.1016/j.febslet.2004.06.097. PMID 15304342.
- ↑ "Melanoma genome sequencing reveals frequent PREX2 mutations". Nature 485 (7399): 502–6. May 2012. doi:10.1038/nature11071. PMID 22622578. PMC 3367798. Bibcode: 2012Natur.485..502B. https://dash.harvard.edu/bitstream/handle/1/10579381/3367798.pdf?sequence=1.
Further reading
- "P-Rex2, a new guanine-nucleotide exchange factor for Rac". FEBS Lett. 572 (1–3): 172–6. August 2004. doi:10.1016/j.febslet.2004.06.096. PMID 15304343.
- "P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration". J. Biol. Chem. 282 (32): 23708–15. August 2007. doi:10.1074/jbc.M703771200. PMID 17565979.
- "Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2". J. Biol. Chem. 280 (30): 27508–12. July 2005. doi:10.1074/jbc.M412495200. PMID 15897194.
- "Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a". Science 325 (5945): 1261–5. September 2009. doi:10.1126/science.1173569. PMID 19729658. Bibcode: 2009Sci...325.1261F.
- Leslie NR (2009). "P-REX2a driving tumorigenesis by PTEN inhibition". Sci Signal 2 (94): pe68. doi:10.1126/scisignal.294pe68. PMID 19861688.
 |
