Biology:PRINS (gene)
From HandWiki
Short description: Non-coding RNA in the species Homo sapiens
 Generic protein structure example |
PRINS (psoriasis associated RNA induced by stress) is a long non-coding RNA. Its expression is induced by stress, and it may have a protective role in cells exposed to stress. It is over-expressed in the skin of patients with psoriasis.[1] It regulates G1P3, a gene encoding a protein with anti-apoptotic effects in keratinocytes. Overexpression of PRINS may contribute to psoriasis via the down-regulation of G1P3.[2]
See also
- Long noncoding RNA
References
- ↑ "Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS". J. Biol. Chem. 280 (25): 24159–24167. June 2005. doi:10.1074/jbc.M501704200. PMID 15855153.
- ↑ "The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS". Exp. Dermatol. 19 (3): 269–278. March 2010. doi:10.1111/j.1600-0625.2010.01066.x. PMID 20377629.
Further reading
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–45. 2004. doi:10.1038/ng1285. PMID 14702039.
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