Biology:Passenger leukocyte
From HandWiki
Short description: Type of cell
In tissue and organ transplantation, the passenger leukocyte theory is the proposition that leucocytes within a transplanted allograft sensitize the recipient's alloreactive T-lymphocytes, causing transplant rejection.[1]
The concept was first proposed by George Davis Snell[2] and the term coined in 1968 when Elkins and Guttmann showed that leukocytes present in a donor graft initiate an immune response in the recipient of a transplant.[3]
See also
- History of immunology
References
- ↑ Thaunat, Olivier; Morelon, Emmanuel (2007). "Modulation of Immunogenicity". in Lanzetta, Marco; Dubernard, Jean-Michel. Hand transplantation. Springer. pp. 210–1. ISBN 978-88-470-0374-3. https://books.google.com/books?id=McxJAAAAQBAJ&pg=PA210.
- ↑ Snell, George D. (1957). "The homograft reaction". Annual Review of Microbiology 11: 439–58. doi:10.1146/annurev.mi.11.100157.002255. PMID 13470828.
- ↑ Elkins, William L.; Guttmann, Ronald D. (1968). "Pathogenesis of a local graft versus host reaction: immunogenicity of circulating host leukocytes". Science 159 (3820): 1250–1. doi:10.1126/science.159.3820.1250. PMID 4886081. Bibcode: 1968Sci...159.1250E.
Further reading
- Audet, Maxime; Panaro, Fabrizio; Piardi, Tullio; Huang, Ping; Cag, Murat; Cinqualbre, Jacques; Wolf, Philippe (2008). "Passenger Lymphocyte Syndrome and Liver Transplantation". Clinical and Developmental Immunology 2008: 715769. doi:10.1155/2008/715769. PMID 19277202.
- Demetris, AJ; Murase, N; Rao, AS; Fung, JJ; Starzl, TE (1995). "The dichotomous functions of passenger leukocytes in solid-organ transplantation". Advances in Nephrology from the Necker Hospital 24: 341–54. PMID 7572418.
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