Biology:Peptidylamidoglycolate lyase

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peptidylamidoglycolate lyase
Identifiers
EC number4.3.2.5
CAS number131689-50-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The enzyme peptidylamidoglycolate lyase (EC 4.3.2.5) catalyzes the chemical reaction

[peptide]-(2S)-2-hydroxyglycine = [peptide]-amide + glyoxylate

This enzyme belongs to the family of lyases, specifically amidine lyases. The systematic name of this enzyme class is [peptide]-(2S)-2-hydroxyglycine peptidyl-amide-lyase (glyoxylate-forming). Other names in common use include α-hydroxyglycine amidating dealkylase, peptidyl-α-hydroxyglycine α-amidating lyase, HGAD, PGL, PAL, and peptidylamidoglycolate peptidylamide-lyase.

References

  • "A novel enzyme from bovine neurointermediate pituitary catalyzes dealkylation of α-hydroxyglycine derivatives, thereby functioning sequentially with peptidylglycine α-amidating monooxygenase in peptide amidation". Biochemistry 29 (26): 6115–20. 1990. doi:10.1021/bi00478a001. PMID 2207061.