Biology:Peptidylamidoglycolate lyase
From HandWiki
| peptidylamidoglycolate lyase | |||||||||
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| Identifiers | |||||||||
| EC number | 4.3.2.5 | ||||||||
| CAS number | 131689-50-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme peptidylamidoglycolate lyase (EC 4.3.2.5) catalyzes the chemical reaction
- [peptide]-(2S)-2-hydroxyglycine = [peptide]-amide + glyoxylate
This enzyme belongs to the family of lyases, specifically amidine lyases. The systematic name of this enzyme class is [peptide]-(2S)-2-hydroxyglycine peptidyl-amide-lyase (glyoxylate-forming). Other names in common use include α-hydroxyglycine amidating dealkylase, peptidyl-α-hydroxyglycine α-amidating lyase, HGAD, PGL, PAL, and peptidylamidoglycolate peptidylamide-lyase.
References
- "A novel enzyme from bovine neurointermediate pituitary catalyzes dealkylation of α-hydroxyglycine derivatives, thereby functioning sequentially with peptidylglycine α-amidating monooxygenase in peptide amidation". Biochemistry 29 (26): 6115–20. 1990. doi:10.1021/bi00478a001. PMID 2207061.
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