Biology:Phenylglyoxylate dehydrogenase (acylating)

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In enzymology, a phenylglyoxylate dehydrogenase (acylating; EC is an enzyme that catalyzes the chemical reaction

phenylglyoxylate + NAD+ + CoA-SH [math]\rightleftharpoons[/math] benzoyl-S-CoA + CO2 + NADH

The three substrates of this enzyme are phenylglyoxylate, NAD+, and CoA-SH, whereas its 3 products are benzoyl-S-CoA, CO2, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is phenylglyoxylate:NAD+ oxidoreductase. It has 3 cofactors: FAD, Thiamin diphosphate, and Iron-sulfur.


  • "Phenylglyoxylate:NAD+ oxidoreductase (CoA benzoylating), a new enzyme of anaerobic phenylalanine metabolism in the denitrifying bacterium Azoarcus evansii". Eur. J. Biochem. 251 (3): 907–15. 1998. doi:10.1046/j.1432-1327.1998.2510907.x. PMID 9490067. dehydrogenase (acylating) was the original source. Read more.