Biology:Phosphatidic acid phosphatase 2c
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Lipid phosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the PPAP2C gene.[1][2][3]
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]
References
- ↑ "Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells". DNA Cell Biol 17 (4): 377–85. May 1998. doi:10.1089/dna.1998.17.377. PMID 9570154.
- ↑ "Identification of a novel human phosphatidic acid phosphatase type 2 isoform". FEBS Lett 427 (2): 188–92. Jun 1998. doi:10.1016/S0014-5793(98)00421-9. PMID 9607309.
- ↑ 3.0 3.1 "Entrez Gene: PPAP2C phosphatidic acid phosphatase type 2C". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8612.
Further reading
- "Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase.". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1): L1–23. 2003. doi:10.1152/ajplung.00029.2002. PMID 12471011.
- "Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts.". J. Biol. Chem. 281 (14): 9297–306. 2006. doi:10.1074/jbc.M511710200. PMID 16467304.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile.". Genesis 27 (4): 137–40. 2000. doi:10.1002/1526-968X(200008)27:4<137::AID-GENE10>3.0.CO;2-4. PMID 10992322.
- "Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.". J. Biol. Chem. 273 (34): 22059–67. 1998. doi:10.1074/jbc.273.34.22059. PMID 9705349.
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