Biology:Picornavirus internal ribosome entry site (IRES)
| Picornavirus internal ribosome entry site (IRES) | |
|---|---|
 Predicted secondary structure and sequence conservation of IRES_Picorna | |
| Identifiers | |
| Symbol | IRES_Picorna |
| Rfam | RF00229 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Viruses |
| GO | 0043022 |
| SO | 0000243 |
| PDB structures | PDBe |
This family represents the Picornavirus internal ribosome entry site (IRES) element present in their 5' untranslated region.[1] These elements were discovered in picornaviruses.[2] They are cis-acting RNA sequences that adopt diverse three-dimensional structures, recruit the translation machinery and that often operate in association with specific RNA-binding proteins.[2] IRES elements allow cap and end-independent translation of mRNA in the host cell. It has been found that La autoantigen (La) is required for Coxsackievirus B3 (CVB3) IRES-mediated translation, and it has been suggested that La may be required for the efficient translation of the viral RNA in the pancreas.[3][4] Based on their secondary structure, picornavirus IRES are grouped into four main types. Type I comprises enteroand rhinovirus IRES and type II, those of cardio- and aphthovirus, among others. Type III is used to name hepatitis A IRES.[2]
References
- ↑ Fernández-Miragall, Olga; Quinto, Sonia López de; Martínez-Salas, Encarnación (February 2009). "Relevance of RNA structure for the activity of picornavirus IRES elements" (in en). Virus Research 139 (2): 172–182. doi:10.1016/j.virusres.2008.07.009. PMID 18692097.
- ↑ 2.0 2.1 2.2 Martínez-Salas, Encarnación; Francisco-Velilla, Rosario; Fernandez-Chamorro, Javier; Lozano, Gloria; Diaz-Toledano, Rosa (August 2015). "Picornavirus IRES elements: RNA structure and host protein interactions" (in en). Virus Research 206: 62–73. doi:10.1016/j.virusres.2015.01.012. PMID 25617758.
- ↑ "La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA". Nucleic Acids Research 30 (20): 4500–4508. October 2002. doi:10.1093/nar/gkf583. PMID 12384597.
- ↑ "Structural and functional analysis of the 5' untranslated region of coxsackievirus B3 RNA: In vivo translational and infectivity studies of full-length mutants". Virology 265 (2): 206–217. December 1999. doi:10.1006/viro.1999.0048. PMID 10600593.
External links
- http://rfam.xfam.org/family/RF00229 Picornavirus internal ribosome entry site (IRES)
- Page for Picornavirus internal ribosome entry site (IRES) at Rfam
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