Biology:Piscarinine
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thumb|150px|2D Structure of Piscarinine A and Piscarinine B Piscarinines are bioactive alkaloid isolates of Penicillium piscarium NKM F-961 [1] and Penicillium piscarium Westling [2] that belong to a class of naturally occurring 2,5-diketopiperazines.[3] The cytotoxic dehydroproline tryptophan derivatives piscarinines A and B were shown to be active against the prostate cancer cell line LNCAP [2] (IC50 values were 2.2 and 1.9 μg/mL for piscarinine A and B, respectively).
References
- ↑ "Piscarinines, new polycyclic diketopiperazine alkaloids from Penicillium piscarium NKM F-691". Natural Product Letters 14 (5): 333–340. September 2000. doi:10.1080/10575630008043765.
- ↑ 2.0 2.1 "Effect of various factors on the biosynthesis of piscarinines, secondary metabolites of the fungus Penicillium piscarium Westling". Applied Biochemistry and Microbiology 44 (6): 608–612. November 2008. doi:10.1134/S0003683808060082. PMID 19145974.
- ↑ Borthwick AD (May 2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products". Chemical Reviews 112 (7): 3641–3716. doi:10.1021/cr200398y. PMID 22575049.
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