Biology:Plasmepsin II
From HandWiki
| Plasmepsin II | |||||||||
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| Identifiers | |||||||||
| EC number | 3.4.23.39 | ||||||||
| CAS number | 159447-18-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Plasmepsin II (EC 3.4.23.39, aspartic hemoglobinase II, PFAPD) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe-Phe(NO2)-Ser-Phe-Pro-Thr
This enzyme is present in malaria organism, Plasmodium.
References
- ↑ "Sequence, expression and modeled structure of an aspartic proteinase from the human malaria parasite Plasmodium falciparum". Molecular and Biochemical Parasitology 64 (2): 177–90. April 1994. doi:10.1016/0166-6851(94)90024-8. PMID 7935597.
- ↑ "Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway". The Journal of Clinical Investigation 93 (4): 1602–8. April 1994. doi:10.1172/JCI117140. PMID 8163662.
- ↑ "High level expression and characterisation of Plasmepsin II, an aspartic proteinase from Plasmodium falciparum". FEBS Letters 352 (2): 155–8. September 1994. doi:10.1016/0014-5793(94)00940-6. PMID 7925966.
External links
- Plasmepsin+II at the US National Library of Medicine Medical Subject Headings (MeSH)
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