Biology:Polygala tenuifolia
| Polygala tenuifolia | |
|---|---|
| |
Scientific classification 
| |
| Kingdom: | Plantae |
| Clade: | Tracheophytes |
| Clade: | Angiosperms |
| Clade: | Eudicots |
| Clade: | Rosids |
| Order: | Fabales |
| Family: | Polygalaceae |
| Genus: | Polygala |
| Species: | P. tenuifolia
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| Binomial name | |
| Polygala tenuifolia | |
Polygala tenuifolia (yuǎn zhì; Chinese: 远志) is an herb in the family Polygalaceae which is hardy to USDA Zone 6.
Phytochemistry
P. tenuifolia contains tenuifolin, senegenin, and polygalacic acid.[1]
Medicinal uses
Yuan zhi is used primarily as an expectorant.[2] It is one of the 50 fundamental herbs used in traditional Chinese medicine, where it is called yuǎn zhì (Chinese: 遠志) and believed to have neuropsychiatric effects. It has been studied as a potential drug source in depression[3] and Alzheimer's.[4] The quality of the herb varies widely, and as of 2020 there have been no toxicological studies or clinical trials.[4] However, in a March, 2025, meta-analysis of 27 studies with 2,334 samples and 19 natural extract treatments, "[t]he most striking result was that the root extract of Polygala tenuifolia ... had the highest ranking for improving overall cognitive function".[5]
References
- ↑ Deng, X.; Zhao, S.; Liu, X.; Han, L.; Wang, R.; Hao, H.; Jiao, Y.; Han, S. et al. (2020). "Polygala tenuifolia: a source for anti-Alzheimer's disease drugs". Pharmaceutical Biology 58 (1): 410–416. doi:10.1080/13880209.2020.1758732. PMID 32429787.
- ↑ "Polygala tenuifolia - Willd. database report". Plants for A Future. 1996–2012. https://www.pfaf.org/user/Plant.aspx?LatinName=Polygala+tenuifolia.
- ↑ Shin, Im-Joon; Son, Sung Un; Park, Hyunwoo; Kim, Yoorim; Park, Sung Hyun; Swanberg, Kelley; Shin, Joo-Yeon; Ha, Sang-Kyu et al. (2014). "Preclinical evidence of rapid-onset antidepressant-like effect in Radix Polygalae extract". PLOS ONE 9 (2). doi:10.1371/journal.pone.0088617. ISSN 1932-6203. PMID 24520403. Bibcode: 2014PLoSO...988617S.
- ↑ 4.0 4.1 Deng, Xinxin; Zhao, Shipeng; Liu, Xinqi; Han, Lu; Wang, Ruizhou; Hao, Huifeng; Jiao, Yanna; Han, Shuyan et al. (2020-01-01). "Polygala tenuifolia: a source for anti-Alzheimer's disease drugs" (in en). Pharmaceutical Biology 58 (1): 410–416. doi:10.1080/13880209.2020.1758732. ISSN 1388-0209. PMID 32429787.
- ↑ Wang, Zhi-Yuan; Deng, Ya-Lu; Zhou, Ting-Yuan; Yi, Liu; Cao, Yu (26 March 2025). "Effects of natural extracts in cognitive function of healthy adults: a systematic review and network meta-analysis.". Frontiers in Pharmacology 16. https://doi.org/10.3389/fphar.2025.1573034.
Wikidata ☰ Q1043050 entry
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