Biology:Presepsin
From HandWiki
Short description: Biomarker for the diagnosis of infections
Presepsin (soluble CD14 subtype, sCD14-ST) is a 13-kDa-cleavage product of CD14 receptor.[1]
Function
Presepsin is a soluble PRR. Presepsin in the circulation is an indicator of monocyte-macrophage activation in response to pathogens.[1]
Clinical relevance
Several clinical studies have demonstrated that presepsin is a specific and sensitive marker for the diagnosis, severity assessment and outcome prediction of sepsis.[2][3][4] In addition, presepsin can be used for diagnosing infections in patients with a chronic inflammatory condition, such as liver cirrhosis.[5]
References
- ↑ 1.0 1.1 "Presepsin (sCD14-ST), an innate immune response marker in sepsis". Clinica Chimica Acta; International Journal of Clinical Chemistry 450: 97–103. October 2015. doi:10.1016/j.cca.2015.06.026. PMID 26164388.
- ↑ "Role of biomarkers in the management of antibiotic therapy: an expert panel review: I - currently available biomarkers for clinical use in acute infections". Annals of Intensive Care 3 (1): 22. July 2013. doi:10.1186/2110-5820-3-22. PMID 23837559.
- ↑ "Presepsin as a diagnostic marker for sepsis: evidence from a bivariate meta-analysis". Therapeutics and Clinical Risk Management 11: 1027–33. 2015. doi:10.2147/TCRM.S84811. PMID 26170681.
- ↑ "Accuracy of Presepsin in Sepsis Diagnosis: A Systematic Review and Meta-Analysis". PLOS ONE 10 (7): e0133057. 2015. doi:10.1371/journal.pone.0133057. PMID 26192602. Bibcode: 2015PLoSO..1033057W.
- ↑ "Presepsin teardown - pitfalls of biomarkers in the diagnosis and prognosis of bacterial infection in cirrhosis". World Journal of Gastroenterology 22 (41): 9172–9185. November 2016. doi:10.3748/wjg.v22.i41.9172. PMID 27895404.
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