Biology:Prevotella-2 RNA motif
| Prevotella-2 | |
|---|---|
 Consensus secondary structure and sequence conservation of Prevotella-2 RNA | |
| Identifiers | |
| Symbol | Prevotella-2 |
| Rfam | RF03043 |
| Other data | |
| RNA type | Gene; sRNA |
| SO | 0001263 |
| PDB structures | PDBe |
The Prevotella-2 RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] Energetically stable tetraloops often occur in this motif. Prevotella-2 motif RNAs are found in the bacterial genus Prevotella.
Nearly all Prevotella-2 RNAs occur upstream of genes that encode sodium/proton antiporters. These data suggest that the RNAs function as cis-regulatory elements. However, one Prevotella-2 RNA is located upstream of a gene encoded on the opposite DNA strand, which would be unlikely for a cis-regulatory function in bacteria. Therefore, it is also possible that Prevotella-2 RNAs are small RNAs that operate in trans. In this model, their association with sodium/proton antiporters would be a coincidence. Most Prevotella-2 RNAs are followed by a Rho-independent transcription terminator. If the RNAs function in cis, these transcript terminators might be a part of the mechanism used to achieve gene regulation. If, on the other hand, Prevotella-2 RNAs correspond to small RNAs, the terminators may simply terminate the transcript containing this non-coding RNA.
References
- ↑ "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. October 2017. doi:10.1093/nar/gkx699. PMID 28977401.
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