Biology:Proboscipedia (fly gene)
| Homeotic protein Proboscipedia | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | pb | ||||||
| UniProt | P31264 | ||||||
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Proboscipedia (pb) is a protein coding gene in Drosophila melanogaster.
Function
This hox gene participates in the development of the labial and maxillary palps and mouthparts in the Drosophila fly. The pb gene is known to regulate the location of the antenna, maxillary palp, tarsus and proboscis identities.[1]
Taxonomy
Proboscipedia belongs to the Antennapedia (Antp) homeobox family and the Proboscipedia subfamily.[2] A homeobox gene is a transcription factor in which a region known as a homeodomain binds to a target gene promoter and controls the differentiation and development of cells. The pb gene is evidenced to be associated with the Sex combs reduced (Scr) gene. Both of these are essential for determination of the proboscis, a long flexible mouthpart in many insects used for the purpose of sucking.[1]
Mutations
Mutated versions of the pb gene result in prothoracic (anterior to thorax) legs from labial palps and maxillary palps that display malformation or smaller size.[3]
References
- ↑ 1.0 1.1 "Proboscipedia". Interactive Fly, Drosophila. 1996. http://cuttlefish.bio.indiana.edu:7082/allied-data/lk/interactive-fly/segment/probosci.htm.
- ↑ "FlyBase: introduction of the Drosophila melanogaster Release 6 reference genome assembly and large-scale migration of genome annotations". Nucleic Acids Research 43 (Database issue): D690-7. January 2015. doi:10.1093/nar/gku1099. PMID 25398896.
- ↑ "Proboscipedia: Drosophila/Vertebrate Genes in Development: Drosophila Antp-like HOM-gen.". HOX Pro db. April 2015. http://www.iephb.nw.ru/hoxpro/pb.html.
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