Biology:Pyruvate dehydrogenase (quinone)
From HandWiki
| Pyruvate dehydrogenase (quinone) | |||||||||
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| Identifiers | |||||||||
| EC number | 1.2.5.1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Pyruvate dehydrogenase (quinone) (EC 1.2.5.1, pyruvate dehydrogenase, pyruvic dehydrogenase, pyruvic (cytochrome b1) dehydrogenase, pyruvate:ubiquinone-8-oxidoreductase, pyruvate oxidase (ambiguous)) is an enzyme with systematic name pyruvate:ubiquinone oxidoreductase.[1][2][3][4][5][6][7][8] This enzyme catalyses the following chemical reaction
- pyruvate + ubiquinone + H2O [math]\displaystyle{ \rightleftharpoons }[/math] acetate + CO2 + ubiquinol
This bacterial enzyme is located on the inner surface of the cytoplasmic membrane.
References
- ↑ "Reconstitution of native Escherichia coli pyruvate oxidase from apoenzyme monomers and FAD". The Journal of Biological Chemistry 257 (21): 12878–86. November 1982. PMID 6752142.
- ↑ "Reactivation of the lipid-depleted pyruvate oxidase system from Escherichia coli with cell envelope neutral lipids". The Journal of Biological Chemistry 250 (18): 7139–46. September 1975. PMID 1100621.
- ↑ "Reconstitution of the membrane-bound, ubiquinone-dependent pyruvate oxidase respiratory chain of Escherichia coli with the cytochrome d terminal oxidase". Biochemistry 23 (3): 445–53. January 1984. doi:10.1021/bi00298a008. PMID 6367818.
- ↑ "In vivo function of Escherichia coli pyruvate oxidase specifically requires a functional lipid binding site". Biochemistry 25 (13): 3748–51. July 1986. doi:10.1021/bi00361a003. PMID 3527254.
- ↑ "Role of the tetrameric structure of Escherichia coli pyruvate oxidase in enzyme activation and lipid binding". The Journal of Biological Chemistry 266 (17): 10959–66. June 1991. PMID 2040613.
- ↑ "Sulfhydryl chemistry detects three conformations of the lipid binding region of Escherichia coli pyruvate oxidase". Biochemistry 36 (39): 11564–73. September 1997. doi:10.1021/bi9709102. PMID 9305946.
- ↑ "Preparation of Escherichia coli pyruvate oxidase utilizing a thiamine pyrophosphate affinity column". Biochimica et Biophysica Acta (BBA) - Enzymology 452 (1): 13–29. November 1976. doi:10.1016/0005-2744(76)90054-1. PMID 791368.
- ↑ "Role of flavin in acetoin production by two bacterial pyruvate oxidases". Archives of Biochemistry and Biophysics 300 (1): 364–71. January 1993. doi:10.1006/abbi.1993.1049. PMID 8424670.
External links
- Pyruvate+dehydrogenase+(quinone) at the US National Library of Medicine Medical Subject Headings (MeSH)
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