Biology:Pyruvate oxidase (CoA-acetylating)
From HandWiki
| pyruvate oxidase (CoA-acetylating) | |||||||||
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| Identifiers | |||||||||
| EC number | 1.2.3.6 | ||||||||
| CAS number | 62213-57-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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A pyruvate oxidase is basically an enzyme that speeds up a chemical reaction.
The by products of this reaction are carbon dioxide , hydrogen peroxide and etc.
In enzymology, a pyruvate oxidase (CoA-acetylating) (EC 1.2.3.6) is an enzyme that catalyzes the chemical reaction
- pyruvate + CoA + O2 [math]\displaystyle{ \rightleftharpoons }[/math] acetyl-CoA + CO2 + H2O2
The 3 substrates of this enzyme are pyruvate, CoA, and O2, whereas its 3 products are acetyl-CoA, CO2, and H2O2.
This enzyme belongs to the family of oxidoreductases , specifically those acting on the aldehyde or oxo group of donor with oxygen as acceptor. The systematic name of this enzyme class is pyruvate:oxygen 2 - oxidoreductase (CoA-acetylating). This enzyme participates in pyruvate metabolism. It employs one cofactor, FAD.
References
- "An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase". J. Biol. Chem. 252 (2): 726–31. 1977. doi:10.1016/S0021-9258(17)32778-3. PMID 13076.
- "Pyruvate oxidase (CoA acetylating) in Entamoeba histolytica". Biochem. Biophys. Res. Commun. 65 (2): 591–6. 1975. doi:10.1016/S0006-291X(75)80187-2. PMID 167776.
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