Biology:QRFP
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human protein.[1]
The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.[2] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.[3]
References
- ↑ "Entrez Gene: P518 RF(Arg-Phe)amide family 26 amino acid peptide". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=347148.
- ↑ "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. July 2003. doi:10.1074/jbc.M302945200. PMID 12714592.
- ↑ "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. November 2003. doi:10.1074/jbc.M305270200. PMID 12960173.
External links
- "Peptide P518 Receptor". IUPHAR/BPS Guide to PHARMACOLOGY. http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=54.
Further reading
- "Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord.". J. Neurochem. 99 (2): 616–27. 2007. doi:10.1111/j.1471-4159.2006.04090.x. PMID 16899066.
- "Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals". Ann. N. Y. Acad. Sci. 1040 (1): 80–3. 2006. doi:10.1196/annals.1327.009. PMID 15891009. Bibcode: 2005NYASA1040...80C.
- "Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity.". Peptides 26 (5): 779–89. 2005. doi:10.1016/j.peptides.2005.01.006. PMID 15808908.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity". Proc. Natl. Acad. Sci. U.S.A. 100 (25): 15247–52. 2004. doi:10.1073/pnas.2434676100. PMID 14657341. Bibcode: 2003PNAS..10015247C.
- "A new peptidic ligand and its receptor regulating adrenal function in rats.". J. Biol. Chem. 278 (47): 46387–95. 2004. doi:10.1074/jbc.M305270200. PMID 12960173.
- "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.". J. Biol. Chem. 278 (30): 27652–7. 2003. doi:10.1074/jbc.M302945200. PMID 12714592.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
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