Biology:RAB2A

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Ras-related protein Rab-2A is a protein that in humans is encoded by the RAB2A gene.

Function

Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rabs are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking. The mammalian RAB proteins show striking similarities to the S. cerevisiae YPT1 and SEC4 proteins, Ras-related GTP-binding proteins involved in the regulation of secretion.[supplied by OMIM]

Interactions

RAB2A has been shown to interact with GOLGA2.

Further reading

• "Isoprenoid modification of rab proteins terminating in CC or CXC motifs". Proceedings of the National Academy of Sciences of the United States of America 88 (14): 6264–8. Jul 1991. doi:10.1073/pnas.88.14.6264. PMID 1648736. Bibcode: 1991PNAS...88.6264K. 
• "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion". The Journal of Biological Chemistry 264 (21): 12394–401. Jul 1989. doi:10.1016/S0021-9258(18)63872-4. PMID 2501306. 
• "Nucleotide sequence of a new YPT1-related human cDNA which belongs to the ras gene superfamily". Nucleic Acids Research 16 (21): 10368. Nov 1988. doi:10.1093/nar/16.21.10368. PMID 3057444. 
• "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry 236 (1): 107–13. Apr 1996. doi:10.1006/abio.1996.0138. PMID 8619474. 
• "Rab2 is essential for the maturation of pre-Golgi intermediates". The Journal of Biological Chemistry 271 (46): 29372–9. Nov 1996. doi:10.1074/jbc.271.46.29372. PMID 8910601. 
• "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. Apr 1997. doi:10.1101/gr.7.4.353. PMID 9110174. 
• "Small GTP-binding proteins in human endothelial cells". British Journal of Haematology 103 (1): 15–9. Oct 1998. doi:10.1046/j.1365-2141.1998.00965.x. PMID 9792283. 
• "General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications". Biochemistry 38 (36): 11711–21. Sep 1999. doi:10.1021/bi990200r. PMID 10512627. 
• "Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells". Journal of Cellular Biochemistry 79 (4): 628–47. Sep 2000. doi:10.1002/1097-4644(20001215)79:4<628::AID-JCB120>3.0.CO;2-T. PMID 10996854. 
• "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic". The Journal of Cell Biology 155 (6): 877–83. Dec 2001. doi:10.1083/jcb.200108079. PMID 11739401. 
• "Molecular cloning and characterization of a novel human Rab ( Rab2B) gene". Journal of Human Genetics 47 (10): 548–51. 2002. doi:10.1007/s100380200083. PMID 12376746. 
• "Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation". The Journal of Biological Chemistry 278 (52): 52524–30. Dec 2003. doi:10.1074/jbc.M309343200. PMID 14570876. 
• "Glyceraldehyde-3-phosphate dehydrogenase interacts with Rab2 and plays an essential role in endoplasmic reticulum to Golgi transport exclusive of its glycolytic activity". The Journal of Biological Chemistry 279 (52): 54046–52. Dec 2004. doi:10.1074/jbc.M409472200. PMID 15485821. 
• "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". Journal of Proteome Research 5 (11): 3135–44. Nov 2006. doi:10.1021/pr060363j. PMID 17081065. 
• "Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases". Cellular Signalling 19 (11): 2388–99. Nov 2007. doi:10.1016/j.cellsig.2007.07.017. PMID 17716866.