Biology:RAB8A

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene.

Function

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrated. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.

Interactions

RAB8A has been shown to interact with Optineurin and MAP4K2.

Further reading

• "Comparative perinatal mortality under medical care foundations and other delivery models". Inquiry 12 (1): 10–7. Mar 1975. PMID 123217. 
• "Confirmation and refinement of the localisation of the c-MEL locus on chromosome 19 by physical and genetic mapping". Human Genetics 81 (4): 382–4. Mar 1989. doi:10.1007/BF00283697. PMID 2564840. 
• "A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells". The Journal of Cell Biology 124 (1–2): 101–15. Jan 1994. doi:10.1083/jcb.124.1.101. PMID 8294494. 
• "Isoprenylation of Rab proteins possessing a C-terminal CaaX motif". FEBS Letters 330 (3): 323–8. Sep 1993. doi:10.1016/0014-5793(93)80897-4. PMID 8375503. 
• "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase". Proceedings of the National Academy of Sciences of the United States of America 93 (10): 5151–5. May 1996. doi:10.1073/pnas.93.10.5151. PMID 8643544. Bibcode: 1996PNAS...93.5151R. 
• "Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1". Genomics 43 (1): 107–9. Jul 1997. doi:10.1006/geno.1997.4776. PMID 9226381. 
• "Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases". The Biochemical Journal 333 (Pt 3): 497–504. Aug 1998. doi:10.1042/bj3330497. PMID 9677305. 
• "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Hormone and Metabolic Research 30 (11): 656–62. Nov 1998. doi:10.1055/s-2007-978953. PMID 9918381. 
• "General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications". Biochemistry 38 (36): 11711–21. Sep 1999. doi:10.1021/bi990200r. PMID 10512627. 
• "FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis". Current Biology 10 (24): 1603–6. 2001. doi:10.1016/S0960-9822(00)00864-2. PMID 11137014. 
• "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". The Journal of Biological Chemistry 277 (11): 9212–8. Mar 2002. doi:10.1074/jbc.M112414200. PMID 11773082. 
• "A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport". Molecular Biology of the Cell 13 (9): 3268–80. Sep 2002. doi:10.1091/mbc.E02-03-0143. PMID 12221131. 
• "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". The Journal of Biological Chemistry 278 (17): 15373–80. Apr 2003. doi:10.1074/jbc.M212341200. PMID 12578829. 
• "Rab8B GTPase and junction dynamics in the testis". Endocrinology 144 (4): 1549–63. Apr 2003. doi:10.1210/en.2002-220893. PMID 12639940. 
• "Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells". Molecular Biology of the Cell 18 (1): 47–56. Jan 2007. doi:10.1091/mbc.E06-07-0575. PMID 17050734.