Biology:RAD1 homolog
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Cell cycle checkpoint protein RAD1 is a protein that in humans is encoded by the RAD1 gene.[1][2][3]
Function
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.[3]
Interactions
RAD1 homolog has been shown to interact with:
References
- ↑ "Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis". Genes Dev 12 (16): 2560–73. September 1998. doi:10.1101/gad.12.16.2560. PMID 9716408.
- ↑ "A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene". Genomics 54 (2): 331–7. January 1999. doi:10.1006/geno.1998.5582. PMID 9828137.
- ↑ 3.0 3.1 "Entrez Gene: RAD1 RAD1 homolog (S. pombe)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5810.
- ↑ 4.0 4.1 "Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex". J. Biol. Chem. 274 (2): 567–70. January 1999. doi:10.1074/jbc.274.2.567. PMID 9872989.
- ↑ "Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1". Genomics 79 (4): 487–92. April 2002. doi:10.1006/geno.2002.6737. PMID 11944979.
- ↑ "Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1633–8. February 2003. doi:10.1073/pnas.0437927100. PMID 12578958. Bibcode: 2003PNAS..100.1633B.
- ↑ "The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9". J. Biol. Chem. 275 (38): 29767–71. September 2000. doi:10.1074/jbc.M005782200. PMID 10884395.
- ↑ "ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses". Nature 411 (6840): 969–74. June 2001. doi:10.1038/35082110. PMID 11418864.
- ↑ "Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene". Genomics 82 (6): 644–51. Dec 2003. doi:10.1016/s0888-7543(03)00200-3. PMID 14611806.
- ↑ "Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy". J. Biol. Chem. 277 (18): 15233–6. May 2002. doi:10.1074/jbc.C200129200. PMID 11907025.
- ↑ "A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex". J. Biol. Chem. 277 (28): 25722–7. July 2002. doi:10.1074/jbc.M203079200. PMID 11994305.
- ↑ "Purification and characterization of human DNA damage checkpoint Rad complexes". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11236–41. September 2001. doi:10.1073/pnas.201373498. PMID 11572977. Bibcode: 2001PNAS...9811236L.
Further reading
- "Yeast DNA recombination and repair proteins Rad1 and Rad10 constitute a complex in vivo mediated by localized hydrophobic domains.". Mol. Microbiol. 8 (6): 1177–88. 1993. doi:10.1111/j.1365-2958.1993.tb01662.x. PMID 8361362.
- "A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease.". J. Biol. Chem. 273 (29): 18332–9. 1998. doi:10.1074/jbc.273.29.18332. PMID 9660799.
- "HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control gene.". Nucleic Acids Res. 26 (17): 3971–6. 1998. doi:10.1093/nar/26.17.3971. PMID 9705507.
- "RAD1, a human structural homolog of the Schizosaccharomyces pombe RAD1 cell cycle checkpoint gene.". Genomics 54 (2): 344–7. 1999. doi:10.1006/geno.1998.5589. PMID 9828139.
- "Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex.". J. Biol. Chem. 274 (2): 567–70. 1999. doi:10.1074/jbc.274.2.567. PMID 9872989.
- "cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster.". Genomics 54 (3): 424–36. 1999. doi:10.1006/geno.1998.5587. PMID 9878245.
- "The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1.". Mol. Biol. Cell 10 (6): 1985–95. 1999. doi:10.1091/mbc.10.6.1985. PMID 10359610.
- "Physical interactions among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression.". Genomics 65 (1): 24–33. 2000. doi:10.1006/geno.2000.6142. PMID 10777662.
- "HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins.". J. Biol. Chem. 275 (36): 27909–16. 2000. doi:10.1074/jbc.M000168200. PMID 10846170.
- "Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage.". J. Biol. Chem. 275 (34): 26343–8. 2000. doi:10.1074/jbc.M001244200. PMID 10852904.
- "The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9.". J. Biol. Chem. 275 (38): 29767–71. 2000. doi:10.1074/jbc.M005782200. PMID 10884395.
- "Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complex.". J. Biol. Chem. 276 (28): 25903–9. 2001. doi:10.1074/jbc.M102946200. PMID 11340080.
- "ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses.". Nature 411 (6840): 969–74. 2001. doi:10.1038/35082110. PMID 11418864.
- "The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9.". Biochem. Biophys. Res. Commun. 287 (4): 932–40. 2001. doi:10.1006/bbrc.2001.5685. PMID 11573955. https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=27371.
- "Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin.". Genes Dev. 16 (2): 198–208. 2002. doi:10.1101/gad.950302. PMID 11799063.
- "Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy.". J. Biol. Chem. 277 (18): 15233–6. 2002. doi:10.1074/jbc.C200129200. PMID 11907025.
- "Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1.". Genomics 79 (4): 487–92. 2002. doi:10.1006/geno.2002.6737. PMID 11944979.
- "A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex.". J. Biol. Chem. 277 (28): 25722–7. 2002. doi:10.1074/jbc.M203079200. PMID 11994305.
 |
