Biology:RAP1GAP2

Generic protein structure example

RAP1 GTPase activating protein 2 is a protein in humans that is encoded by the RAP1GAP2 gene.

This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

Further reading

• "Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets". Blood 114 (7): 1396–404. August 2009. doi:10.1182/blood-2008-05-155234. PMID 19528539. 
• "GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease". BMC Cardiovascular Disorders 11: 29. June 2011. doi:10.1186/1471-2261-11-29. PMID 21658281. 
• "Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood-derived human megakaryocytes". Experimental Cell Research 300 (1): 84–93. October 2004. doi:10.1016/j.yexcr.2004.07.011. PMID 15383317. 
• "p2y5/LPA(6) attenuates LPA(1)-mediated VE-cadherin translocation and cell-cell dissociation through G(12/13) protein-Src-Rap1". Cardiovascular Research 92 (1): 149–58. October 2011. doi:10.1093/cvr/cvr154. PMID 21632882. 
• "Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets". Blood 105 (8): 3185–92. April 2005. doi:10.1182/blood-2004-09-3605. PMID 15632203. 
• "Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets". The Journal of Biological Chemistry 283 (4): 2297–306. January 2008. doi:10.1074/jbc.M706825200. PMID 18039662. http://researchrepository.ucd.ie/bitstream/10197/5865/1/RG2-1433-JBC_revision_final.pdf.