Biology:RAP2A

Generic protein structure example

Ras-related protein Rap-2a is a protein that in humans is encoded by the RAP2A gene. RAP2A is a member of the Ras-related protein family.

Interactions

RAP2A has been shown to interact with RUNDC3A, RASSF5 and RALGDS.

Further reading

• "The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis". The Journal of Biological Chemistry 266 (7): 4315–21. Mar 1991. doi:10.1016/S0021-9258(20)64324-1. PMID 1900290. 
• "Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region". Oncogene 3 (2): 201–4. Aug 1988. PMID 3045729. 
• "Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated". The Biochemical Journal 289 ( Pt 2) (Pt 2): 349–55. Jan 1993. doi:10.1042/bj2890349. PMID 8424780. 
• "Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS". The EMBO Journal 16 (18): 5582–91. Sep 1997. doi:10.1093/emboj/16.18.5582. PMID 9312017. 
• "Identification of a specific effector of the small GTP-binding protein Rap2". European Journal of Biochemistry 252 (2): 290–8. Mar 1998. doi:10.1046/j.1432-1327.1998.2520290.x. PMID 9523700. 
• "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". The Journal of Biological Chemistry 274 (13): 8737–45. Mar 1999. doi:10.1074/jbc.274.13.8737. PMID 10085114. 
• "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily". The Journal of Biological Chemistry 274 (19): 13556–62. May 1999. doi:10.1074/jbc.274.19.13556. PMID 10224125. 
• "Structure of the small G protein Rap2 in a non-catalytic complex with GTP". Proteins 37 (3): 465–73. Nov 1999. doi:10.1002/(SICI)1097-0134(19991115)37:3<465::AID-PROT13>3.0.CO;2-O. PMID 10591105. 
• "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs". The Journal of Biological Chemistry 275 (27): 20829–36. Jul 2000. doi:10.1074/jbc.M001113200. PMID 10777494. 
• "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nature Neuroscience 3 (7): 661–9. Jul 2000. doi:10.1038/76615. PMID 10862698. 
• "RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao". The Biochemical Journal 350 Pt 1 (Pt 1): 19–29. Aug 2000. doi:10.1042/0264-6021:3500019. PMID 10926822. 
• "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras". The Journal of Biological Chemistry 276 (45): 42219–25. Nov 2001. doi:10.1074/jbc.M105760200. PMID 11524421. 
• "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene 21 (9): 1381–90. Feb 2002. doi:10.1038/sj.onc.1205192. PMID 11857081. 
• "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon". Oncogene 21 (53): 8105–13. Nov 2002. doi:10.1038/sj.onc.1206003. PMID 12444546. 
• "Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1593 (2–3): 141–9. Feb 2003. doi:10.1016/S0167-4889(02)00365-8. PMID 12581858. 
• "Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase". The Journal of Biological Chemistry 279 (16): 15711–4. Apr 2004. doi:10.1074/jbc.C300542200. PMID 14966141. 
• "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". The Journal of Biological Chemistry 279 (21): 22353–61. May 2004. doi:10.1074/jbc.M312867200. PMID 15031288.