Biology:RALGDS
From HandWiki
 Generic protein structure example |
Ral guanine nucleotide dissociation stimulator is a protein that is encoded by the RALGDS gene in humans.[1][2]
Interactions
RALGDS has been shown to interact with:
- Arrestin beta 1,[3]
- Arrestin beta 2,[3]
- HRAS,[1][4][5][6][7][8][9][10]
- KRAS,[4][6]
- MRAS,[11][12]
- RAP1A,[5][13]
- RAP2A,[13]
- RAPGEF2,[4] and
- RRAS.[4]
References
- ↑ 1.0 1.1 "Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator". Proc Natl Acad Sci U S A 91 (23): 11089–93. December 1994. doi:10.1073/pnas.91.23.11089. PMID 7972015. Bibcode: 1994PNAS...9111089H.
- ↑ "Entrez Gene: RALGDS ral guanine nucleotide dissociation stimulator". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5900.
- ↑ 3.0 3.1 "Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization". Nat. Cell Biol. 4 (8): 547–55. August 2002. doi:10.1038/ncb821. PMID 12105416.
- ↑ 4.0 4.1 4.2 4.3 "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609–13. December 1994. doi:10.1073/pnas.91.26.12609. PMID 7809086. Bibcode: 1994PNAS...9112609S.
- ↑ 5.0 5.1 "The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9064–9. August 2000. doi:10.1073/pnas.97.16.9064. PMID 10922060. Bibcode: 2000PNAS...97.9064B.
- ↑ 6.0 6.1 "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev. 14 (8): 895–900. April 2000. doi:10.1101/gad.14.8.895. PMID 10783161.
- ↑ "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. May 2004. doi:10.1074/jbc.M312867200. PMID 15031288.
- ↑ "RalGDS functions in Ras- and cAMP-mediated growth stimulation". J. Biol. Chem. 272 (9): 5600–5. February 1997. doi:10.1074/jbc.272.9.5600. PMID 9038168.
- ↑ "Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras". Cell 89 (3): 457–67. May 1997. doi:10.1016/s0092-8674(00)80226-3. PMID 9150145.
- ↑ "Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells". Mol. Cell. Biol. 17 (6): 3047–55. June 1997. doi:10.1128/MCB.17.6.3047. PMID 9154803.
- ↑ "Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution". Oncogene 15 (22): 2675–85. November 1997. doi:10.1038/sj.onc.1201674. PMID 9400994.
- ↑ "M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line". Blood 94 (7): 2433–44. October 1999. doi:10.1182/blood.V94.7.2433.419k31_2433_2444. PMID 10498616.
- ↑ 13.0 13.1 "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". J. Biol. Chem. 274 (13): 8737–45. March 1999. doi:10.1074/jbc.274.13.8737. PMID 10085114.
Further reading
- "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609–13. 1995. doi:10.1073/pnas.91.26.12609. PMID 7809086. Bibcode: 1994PNAS...9112609S.
- "Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase". EMBO J. 12 (1): 339–47. 1993. doi:10.1002/j.1460-2075.1993.tb05662.x. PMID 8094051.
- "Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation". EMBO J. 15 (4): 810–6. 1996. doi:10.1002/j.1460-2075.1996.tb00416.x. PMID 8631302.
- "RalGDS functions in Ras- and cAMP-mediated growth stimulation". J. Biol. Chem. 272 (9): 5600–5. 1997. doi:10.1074/jbc.272.9.5600. PMID 9038168.
- "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates". EMBO J. 16 (8): 1921–33. 1997. doi:10.1093/emboj/16.8.1921. PMID 9155018.
- "Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling". Nat. Struct. Biol. 4 (9): 694–9. 1997. doi:10.1038/nsb0997-694. PMID 9302994.
- "Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1". Ann. Hum. Genet. 61 (Pt 4): 299–305. 1997. doi:10.1046/j.1469-1809.1997.6140299.x. PMID 9365783.
- "Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution". Oncogene 15 (22): 2675–85. 1998. doi:10.1038/sj.onc.1201674. PMID 9400994.
- "Interactions of the amino acid residue at position 31 of the c-Ha-Ras protein with Raf-1 and RalGDS". J. Biol. Chem. 273 (13): 7737–42. 1998. doi:10.1074/jbc.273.13.7737. PMID 9516482.
- "Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes". EMBO J. 17 (9): 2554–65. 1998. doi:10.1093/emboj/17.9.2554. PMID 9564038.
- "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". J. Biol. Chem. 274 (13): 8737–45. 1999. doi:10.1074/jbc.274.13.8737. PMID 10085114.
- "M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line". Blood 94 (7): 2433–44. 1999. doi:10.1182/blood.V94.7.2433.419k31_2433_2444. PMID 10498616.
- "Biochemical characterization of the Ras-related GTPases Rit and Rin". Arch. Biochem. Biophys. 371 (2): 207–19. 1999. doi:10.1006/abbi.1999.1448. PMID 10545207.
- "[Refined chromosome assignment of human novel H-RalGDS gene on chromosome 9q34.1 by using radiation hybrid genebridge 4 panel]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi 17 (1): 1–5. 2000. PMID 10653898.
- "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. 2000. doi:10.1093/dnares/7.1.65. PMID 10718198.
- "Structure characterization of human RalGDS gene, and the identification of its novel variant". Mol. Biol. Rep. 27 (4): 209–16. 2001. doi:10.1023/A:1011043122220. PMID 11455956.
- "Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation". J. Biol. Chem. 277 (12): 9966–75. 2002. doi:10.1074/jbc.M109059200. PMID 11788587.
- "Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K". Oncogene 21 (6): 937–46. 2002. doi:10.1038/sj.onc.1205144. PMID 11840339.
- "PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism". EMBO J. 21 (6): 1327–38. 2002. doi:10.1093/emboj/21.6.1327. PMID 11889038.
PDB gallery | |
|---|---|
|
 |
