Biology:RASD2
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 Generic protein structure example |
GTP-binding protein Rhes is a protein that in humans is encoded by the RASD2 gene.[1][2][3][4]
This gene encodes a Ras-related protein that is produced largely in the striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades.[4]
References
- ↑ "Genes expressed in human tumor endothelium". Science 289 (5482): 1197–202. Aug 2000. doi:10.1126/science.289.5482.1197. PMID 10947988. Bibcode: 2000Sci...289.1197S.
- ↑ "Rhes: A striatal-specific Ras homolog related to Dexras1". J Neurosci Res 57 (6): 782–8. Oct 1999. doi:10.1002/(SICI)1097-4547(19990915)57:6<782::AID-JNR3>3.0.CO;2-9. PMID 10467249.
- ↑ "The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors". Oncogene 23 (2): 559–68. Jan 2004. doi:10.1038/sj.onc.1207161. PMID 14724584.
- ↑ 4.0 4.1 "Entrez Gene: RASD2 RASD family, member 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23551.
Further reading
- "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- "Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic β-cell". Br. J. Pharmacol. 136 (1): 31–6. 2002. doi:10.1038/sj.bjp.0704680. PMID 11976265.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. 2005. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. 2005. doi:10.1126/science.1105776. PMID 15761153. Bibcode: 2005Sci...307.1621B.
- "Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process". Biochem. Biophys. Res. Commun. 349 (2): 809–15. 2006. doi:10.1016/j.bbrc.2006.08.102. PMID 16945334.
- "Ras homolog enriched in striatum inhibits the functional activity of wild type thyrotropin, follicle-stimulating hormone, luteinizing hormone receptors and activating thyrotropin receptor mutations by altering their expression in COS-7 cells". J. Endocrinol. Invest. 30 (4): 279–84. 2007. doi:10.1007/bf03346294. PMID 17556863.
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