Biology:RASIP1

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example


Ras-interacting protein 1 (RASIP1), also known as RAIN, is a protein that in humans is encoded by the RASIP1 gene.[1]

Function

  • It is required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis.[2]
  • Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis.[3][4][5]
  • Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells.[6][7]

Clinical significance

A recent genome-wide association study (GWAS) has found that genetic variations in RASIP1 are associated with late-onset sporadic Alzheimer’s disease (LOAD). However, it's unknown how RASIP1 mutation contributes to disease.[8]

References

  1. ↑ "RASIP1 - Ras-interacting protein 1 - Homo sapiens (Human) - RASIP1 gene & protein" (in en). https://www.uniprot.org/uniprot/Q5U651.  CC-BY icon.svg Text was copied from this source, which is available under a Creative Commons Attribution 4.0 International License.
  2. ↑ "Regulation of vascular endothelial junction stability and remodeling through Rap1-Rasip1 signaling". Cell Adhesion & Migration 8 (2): 76–83. 2014. doi:10.4161/cam.28115. PMID 24622510. 
  3. ↑ "Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth". Angiogenesis 19 (2): 173–190. April 2016. doi:10.1007/s10456-016-9498-5. PMID 26897025. 
  4. ↑ "Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions". Development 145 (17): dev165092. August 2018. doi:10.1242/dev.165092. PMID 30042182. 
  5. ↑ "Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation". Developmental Biology 329 (2): 269–279. May 2009. doi:10.1016/j.ydbio.2009.02.033. PMID 19272373. 
  6. ↑ "Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II". Circulation Research 119 (7): 810–826. September 2016. doi:10.1161/CIRCRESAHA.116.309094. PMID 27486147. 
  7. ↑ "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization" (in English). The Journal of Biological Chemistry 279 (21): 22353–22361. May 2004. doi:10.1074/jbc.M312867200. PMID 15031288. 
  8. ↑ "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease". Nature Genetics 53 (9): 1276–1282. September 2021. doi:10.1038/s41588-021-00921-z. PMID 34493870. https://research.vu.nl/en/publications/61f01aa9-6dc7-4213-be2a-d3fe622db488. 




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