Biology:RDH11
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Retinol dehydrogenase 11 is an enzyme that in humans is encoded by the RDH11 gene.[1][2][3][4]
RHD11, a member of the short-chain dehydrogenase/reductase (SDR) superfamily of oxidoreductases, is expressed at high levels in prostate epithelium, and its expression is regulated by androgens.[supplied by OMIM][4]
Clinical significance
Mutations in RDH11 are associated to retinitis pigmentosa.[5]
References
- ↑ "Dual-substrate Specificity Short Chain Retinol Dehydrogenases from the Vertebrate Retina". J Biol Chem 277 (47): 45537–46. Nov 2002. doi:10.1074/jbc.M208882200. PMID 12226107.
- ↑ "Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line". Blood 84 (1): 189–99. Aug 1994. doi:10.1182/blood.V84.1.189.189. PMID 8018917.
- ↑ "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact 178 (1–3): 94–8. Feb 2009. doi:10.1016/j.cbi.2008.10.040. PMID 19027726.
- ↑ 4.0 4.1 "Entrez Gene: RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51109.
- ↑ Xie, Y. A.; Lee, W; Cai, C; Gambin, T; Nõupuu, K; Sujirakul, T; Ayuso, C; Jhangiani, S et al. (2014). "New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11". Human Molecular Genetics 23 (21): 5774–5780. doi:10.1093/hmg/ddu291. PMID 24916380.
Further reading
- Lai CH; Chou CY; Ch'ang LY et al. (2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMID 10810093.
- Lin B; White JT; Ferguson C et al. (2001). "Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium". Cancer Res. 61 (4): 1611–8. PMID 11245473.
- Kedishvili NY; Chumakova OV; Chetyrkin SV et al. (2002). "Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1)". J. Biol. Chem. 277 (32): 28909–15. doi:10.1074/jbc.M202588200. PMID 12036956.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Li K; Wang L; Cheng J et al. (2003). "Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus". World J. Gastroenterol. 9 (2): 300–3. doi:10.3748/wjg.v9.i2.300. PMID 12532453.
- "Properties of short-chain dehydrogenase/reductase RalR1: characterization of purified enzyme, its orientation in the microsomal membrane, and distribution in human tissues and cell lines". Biochemistry 42 (50): 14838–45. 2004. doi:10.1021/bi035288u. PMID 14674758.
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Otsuki T; Ota T; Nishikawa T et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- "Photoreceptor retinol dehydrogenases. An attempt to characterize the function of Rdh11". Adv. Exp. Med. Biol.. Advances in Experimental Medicine and Biology 572: 505–11. 2007. doi:10.1007/0-387-32442-9_70. ISBN 978-0-387-28464-4. PMID 17249616. https://archive.org/details/isbn_9780387284644/page/505.
- "Mapping of transcription start sites of human retina expressed genes". BMC Genomics 8: 42. 2007. doi:10.1186/1471-2164-8-42. PMID 17286855.
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