Biology:RGS19
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Regulator of G-protein signaling 19 is a protein that in humans is encoded by the RGS19 gene.[1][2]
G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling.[2][3]
Interactions
RGS19 has been shown to interact with GNAO1,[4][5] GIPC1,[6] OSTM1,[7] GNAI1,[4][5] GNAI3[1][4][5] and GNAZ.[4][8]
References
- ↑ 1.0 1.1 "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proc Natl Acad Sci U S A 92 (25): 11916–20. January 1996. doi:10.1073/pnas.92.25.11916. PMID 8524874.
- ↑ 2.0 2.1 "Entrez Gene: RGS19 regulator of G-protein signalling 19". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10287.
- ↑ "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell 86 (3): 445–452. 1996. doi:10.1016/S0092-8674(00)80117-8. PMID 8756726.
- ↑ 4.0 4.1 4.2 4.3 De Vries, L; Elenko E; Hubler L; Jones T L; Farquhar M G (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. ISSN 0027-8424. PMID 8986788. Bibcode: 1996PNAS...9315203D.
- ↑ 5.0 5.1 5.2 Woulfe, D S; Stadel J M (June 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. (UNITED STATES) 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. ISSN 0021-9258. PMID 10364213.
- ↑ Lou, X; Yano H; Lee F; Chao M V; Farquhar M G (March 2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways". Mol. Biol. Cell (United States) 12 (3): 615–27. doi:10.1091/mbc.12.3.615. ISSN 1059-1524. PMID 11251075.
- ↑ Fischer, Thierry; De Vries Luc; Meerloo Timo; Farquhar Marilyn Gist (July 2003). "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (14): 8270–5. doi:10.1073/pnas.1432965100. ISSN 0027-8424. PMID 12826607. Bibcode: 2003PNAS..100.8270F.
- ↑ Fan, X; Brass L F; Poncz M; Spitz F; Maire P; Manning D R (October 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. (UNITED STATES) 275 (41): 32129–34. doi:10.1074/jbc.M004577200. ISSN 0021-9258. PMID 10906137.
Further reading
- "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell 86 (3): 445–452. 1996. doi:10.1016/S0092-8674(00)80117-8. PMID 8756726.
- "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15203–8. 1997. doi:10.1073/pnas.93.26.15203. PMID 8986788. Bibcode: 1996PNAS...9315203D.
- "Control of the expression and activity of the Galpha-interacting protein (GAIP) in human intestinal cells". J. Biol. Chem. 272 (39): 24599–603. 1997. doi:10.1074/jbc.272.39.24599. PMID 9305927.
- "RGS-GAIP, a GTPase-activating protein for Galphai heterotrimeric G proteins, is located on clathrin-coated vesicles". Mol. Biol. Cell 9 (5): 1123–34. 1998. doi:10.1091/mbc.9.5.1123. PMID 9571244.
- "The regulators of G protein signaling (RGS) domains of RGS4, RGS10 and GAIP retain GTPase activating protein activity in vitro". Proc Natl Acad Sci USA 94 (14): 7216–20. 1997. doi:10.1073/pnas.94.14.7216. PMID 9207071. Bibcode: 1997PNAS...94.7216P.
- "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily". J. Biol. Chem. 273 (40): 26014–25. 1998. doi:10.1074/jbc.273.40.26014. PMID 9748280.
- "GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP". Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12340–5. 1998. doi:10.1073/pnas.95.21.12340. PMID 9770488. Bibcode: 1998PNAS...9512340D.
- "Clathrin-coated vesicles bearing GAIP possess GTPase-activating protein activity in vitro". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6722–7. 1999. doi:10.1073/pnas.96.12.6722. PMID 10359779. Bibcode: 1999PNAS...96.6722F.
- "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. 274 (25): 17718–24. 1999. doi:10.1074/jbc.274.25.17718. PMID 10364213.
- "Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling". J. Mol. Biol. 291 (4): 927–39. 1999. doi:10.1006/jmbi.1999.2989. PMID 10452897. https://zenodo.org/record/1229890.
- "MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 3999–4004. 2000. doi:10.1073/pnas.97.8.3999. PMID 10760272. Bibcode: 2000PNAS...97.3999Z.
- "Membrane-associated GAIP is a phosphoprotein and can be phosphorylated by clathrin-coated vesicles". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4040–5. 2000. doi:10.1073/pnas.97.8.4040. PMID 10760275. Bibcode: 2000PNAS...97.4040F.
- "Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells". J. Biol. Chem. 275 (50): 39090–5. 2001. doi:10.1074/jbc.M006198200. PMID 10993892.
- "A core-promoter region functions bi-directionally for human opioid-receptor-like gene ORL1 and its 5'-adjacent gene GAIP". J. Mol. Biol. 304 (3): 259–70. 2000. doi:10.1006/jmbi.2000.4212. PMID 11090272.
- "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways". Mol. Biol. Cell 12 (3): 615–27. 2001. doi:10.1091/mbc.12.3.615. PMID 11251075.
- "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. 2002. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D.
- "GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins". Annual Review of Biochemistry 69: 795–827. 2000. doi:10.1146/annurev.biochem.69.1.795. PMID 10966476.
- "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics 79 (2): 177–85. 2002. doi:10.1006/geno.2002.6693. PMID 11829488.
- "Expression of human GIPC1 in normal tissues, cancer cell lines, and primary tumors". Int. J. Mol. Med. 9 (5): 509–13. 2002. doi:10.3892/ijmm.9.5.509. PMID 11956658.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Gene structure, dual-promoters and mRNA alternative splicing of the human and mouse regulator of G protein signaling GAIP/RGS19". J. Mol. Biol. 325 (4): 721–32. 2003. doi:10.1016/S0022-2836(02)01283-4. PMID 12507475.
- "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8270–5. 2003. doi:10.1073/pnas.1432965100. PMID 12826607. Bibcode: 2003PNAS..100.8270F.
External links
- RGS19 human gene location in the UCSC Genome Browser.
- RGS19 human gene details in the UCSC Genome Browser.
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