Biology:RGS8

Generic protein structure example

Regulator of G-protein signaling 8 is a protein that in humans is encoded by the RGS8 gene.

This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation.

Further reading

• "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell 86 (3): 445–452. 1996. doi:10.1016/S0092-8674(00)80117-8. PMID 8756726. 
• "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. 2001. doi:10.1038/88107. PMID 11329013. 
• "RGS proteins provide biochemical control of agonist-evoked [Ca2+]i oscillations". Molecular Cell 7 (3): 651–660. 2001. doi:10.1016/S1097-2765(01)00211-8. PMID 11463389. 
• "Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner". J Biol Chem 286 (17): 15116–15125. 2011. doi:10.1074/jbc.M110.216234. PMID 21357625. 
• "The regulators of G protein signaling (RGS) domains of RGS4, RGS10 and GAIP retain GTPase activating protein activity in vitro". Proc Natl Acad Sci USA 94 (14): 7216–20. 1997. doi:10.1073/pnas.94.14.7216. PMID 9207071. Bibcode: 1997PNAS...94.7216P. 
• "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity". J Biol Chem 275 (25): 18962–8. 2000. doi:10.1074/jbc.M001128200. PMID 10747990. 
• "GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins.". Annual Review of Biochemistry 69: 795–827. 2000. doi:10.1146/annurev.biochem.69.1.795. PMID 10966476. 
• "Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling.". Proc. Natl. Acad. Sci. U.S.A. 99 (15): 10138–43. 2002. doi:10.1073/pnas.152085999. PMID 12110731. Bibcode: 2002PNAS...9910138S. 
• "Evolution of the regulators of G-protein signaling multigene family in mouse and human.". Genomics 79 (2): 177–85. 2002. doi:10.1006/geno.2002.6693. PMID 11829488. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. 
• "The mechanism of membrane-translocation of regulator of G-protein signaling (RGS) 8 induced by Galpha expression.". J. Neurochem. 88 (1): 161–8. 2004. doi:10.1046/j.1471-4159.2003.02139.x. PMID 14675160. 
• "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system.". Brain Res. Mol. Brain Res. 122 (1): 24–34. 2004. doi:10.1016/j.molbrainres.2003.11.014. PMID 14992813. 
• "Biochemical and electrophysiological analyses of RGS8 function.". Meth. Enzymol.. Methods in Enzymology 390: 129–48. 2005. doi:10.1016/S0076-6879(04)90009-2. ISBN 9780121827953. PMID 15488175. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Participation of RGS8 in the ternary complex of agonist, receptor and G-protein.". Biochem. Soc. Trans. 32 (Pt 6): 1045–7. 2005. doi:10.1042/BST0321045. PMID 15506959. 
• "Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics.". J. Biol. Chem. 280 (14): 13383–94. 2005. doi:10.1074/jbc.M410163200. PMID 15677457. 
• "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G. 
• "Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes". Disease Models & Mechanisms 3 (9–10): 567–580. 2010. doi:10.1242/dmm.003210. PMID 20616094. 
• "New roles for Galpha and RGS proteins: communication continues despite pulling sisters apart". Current Biology 15 (20): R843-54. 2005. doi:10.1016/j.cub.2005.10.008. PMID 16243026.