Biology:RNF111
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
E3 ubiquitin-protein ligase Arkadia is an enzyme that in humans is encoded by the RNF111 gene.[1][2]
Function
The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.[2]
Interactions
RNF111 has been shown to interact with Mothers against decapentaplegic homolog 7[3] and Mothers against decapentaplegic homolog 3.[3][4]
References
- ↑ "Induction of the mammalian node requires Arkadia function in the extraembryonic lineages". Nature 410 (6830): 825–30. Apr 2001. doi:10.1038/35071095. PMID 11298452. Bibcode: 2001Natur.410..825E.
- ↑ Jump up to: 2.0 2.1 "Entrez Gene: RNF111 ring finger protein 111". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54778.
- ↑ Jump up to: 3.0 3.1 "Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7". The EMBO Journal 22 (24): 6458–70. Dec 2003. doi:10.1093/emboj/cdg632. PMID 14657019.
- ↑ "Arkadia represses the expression of myoblast differentiation markers through degradation of Ski and the Ski-bound Smad complex in C2C12 myoblasts". Bone 44 (1): 53–60. Jan 2009. doi:10.1016/j.bone.2008.09.013. PMID 18950738.
Further reading
- "Vertebrate development: Et in Arkadia". Current Biology 11 (15): R616-9. Aug 2001. doi:10.1016/S0960-9822(01)00367-0. PMID 11516970.
- "Arkadia enhances nodal-related signalling to induce mesendoderm". Nature 410 (6830): 830–4. Apr 2001. doi:10.1038/35071103. PMID 11298453. Bibcode: 2001Natur.410..830N.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16899–903. Dec 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7". The EMBO Journal 22 (24): 6458–70. Dec 2003. doi:10.1093/emboj/cdg632. PMID 14657019.
- "Functional proteomics mapping of a human signaling pathway". Genome Research 14 (7): 1324–32. Jul 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia". The EMBO Journal 25 (8): 1646–58. Apr 2006. doi:10.1038/sj.emboj.7601057. PMID 16601693.
- "Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling". The Journal of Biological Chemistry 282 (28): 20492–501. Jul 2007. doi:10.1074/jbc.M701294200. PMID 17510063.
- "Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation". Molecular and Cellular Biology 27 (17): 6068–83. Sep 2007. doi:10.1128/MCB.00664-07. PMID 17591695.
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