Biology:RNF135
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
RING finger protein 135 is a protein that in humans is encoded by the RNF135 gene.[1][2][3]
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]
Interactions
RNF135 has been shown to interact with RARRES3.[2]
References
- ↑ "Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions". Am J Hum Genet 69 (3): 516–27. Aug 2001. doi:10.1086/323043. PMID 11468690.
- ↑ 2.0 2.1 "Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection". J Biol Chem 284 (2): 807–17. Jan 2009. doi:10.1074/jbc.M804259200. PMID 19017631.
- ↑ 3.0 3.1 "Entrez Gene: RNF135 ring finger protein 135". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84282.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse.". Genes Chromosomes Cancer 37 (2): 111–20. 2003. doi:10.1002/gcc.10206. PMID 12696059.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer.". Oncogene 23 (46): 7734–45. 2004. doi:10.1038/sj.onc.1207921. PMID 15334068.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth.". Nat. Genet. 39 (8): 963–5. 2007. doi:10.1038/ng2083. PMID 17632510.
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