Biology:RNF38

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

RING finger protein 38 is a protein that in humans is encoded by the RNF38 gene.

This gene encodes a protein with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is a zinc-binding domain found in a large set of proteins playing roles in diverse cellular processes including oncogenesis, development, signal transduction, and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

See also

• RING finger domain

Further reading

• Mehrle A; Rosenfelder H; Schupp I et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMID 16381901. 
• Kimura K; Wakamatsu A; Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
• Wiemann S; Arlt D; Huber W et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMID 15489336. 
• Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMID 15489334. 
• Humphray SJ; Oliver K; Hunt AR et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–374. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H. 
• Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039. 
• Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• Eisenberg I; Hochner H; Levi T et al. (2002). "Cloning and characterization of a novel human gene RNF38 encoding a conserved putative protein with a RING finger domain". Biochem. Biophys. Res. Commun. 294 (5): 1169–1176. doi:10.1016/S0006-291X(02)00584-3. PMID 12074600. 
• Xu XR; Huang J; Xu ZG et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–15094. doi:10.1073/pnas.241522398. PMID 11752456. Bibcode: 2001PNAS...9815089X. 
• Wiemann S; Weil B; Wellenreuther R et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMID 11230166. 
• "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. 2001. doi:10.1101/gr.143000. PMID 11076863. 
• "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548. 

External links

• RNF38+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)