Biology:RUVBL2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

RuvB-like 2 (E. coli), also known as RUVBL2, is a human gene coding for a protein belonging to the AAA+ family of proteins.

Function

This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. However, the evidence for whether RUVBL2 has DNA helicase activity is contradictory. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.

Interactions

RUVBL2 has been shown to interact with RuvB-like 1 and Activating transcription factor 2.

Further reading

• "The highly conserved and multifunctional NuA4 HAT complex". Current Opinion in Genetics & Development 14 (2): 147–54. Apr 2004. doi:10.1016/j.gde.2004.02.009. PMID 15196461. 
• "TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a". The Journal of Biological Chemistry 274 (32): 22437–44. Aug 1999. doi:10.1074/jbc.274.32.22437. PMID 10428817. 
• "Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1446 (3): 365–70. Sep 1999. doi:10.1016/S0167-4781(99)00104-9. PMID 10524211. 
• "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research 10 (5): 703–13. May 2000. doi:10.1101/gr.10.5.703. PMID 10810093. 
• "An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc". Molecular Cell 5 (2): 321–30. Feb 2000. doi:10.1016/S1097-2765(00)80427-X. PMID 10882073. 
• "Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis". Cell 102 (4): 463–73. Aug 2000. doi:10.1016/S0092-8674(00)00051-9. PMID 10966108. 
• "Human TIP49b/RUVBL2 gene: genomic structure, expression pattern, physical link to the human CGB/LHB gene cluster on chromosome 19q13.3". Annales de Génétique 43 (2): 69–74. 2000. doi:10.1016/S0003-3995(00)01016-9. PMID 10998447. 
• "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. Nov 2000. doi:10.1101/gr.143000. PMID 11076863. 
• "Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity". The EMBO Journal 19 (22): 6121–30. Nov 2000. doi:10.1093/emboj/19.22.6121. PMID 11080158. 
• "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. Mar 2001. doi:10.1101/gr.GR1547R. PMID 11230166. 
• "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–92. Sep 2000. doi:10.1093/embo-reports/kvd058. PMID 11256614. 
• "TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage". Molecular and Cellular Biology 21 (24): 8398–413. Dec 2001. doi:10.1128/MCB.21.24.8398-8413.2001. PMID 11713276. 
• "BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation". Molecular and Cellular Biology 22 (5): 1307–16. Mar 2002. doi:10.1128/MCB.22.5.1307-1316.2002. PMID 11839798. 
• "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The Journal of Biological Chemistry 277 (43): 40362–7. Oct 2002. doi:10.1074/jbc.M206194200. PMID 12171929. 
• "Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP". Molecular and Cellular Biology 22 (23): 8342–52. Dec 2002. doi:10.1128/MCB.22.23.8342-8352.2002. PMID 12417735. PMC 134055. http://pubman.mpdl.mpg.de/pubman/item/escidoc:641782/component/escidoc:2250325/641782.pdf. 
• "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology 21 (5): 566–9. May 2003. doi:10.1038/nbt810. PMID 12665801. 
• "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". The Journal of Biological Chemistry 278 (44): 42733–6. Oct 2003. doi:10.1074/jbc.C300389200. PMID 12963728. 
• "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science 302 (5648): 1208–12. Nov 2003. doi:10.1126/science.1088401. PMID 14615539. Bibcode: 2003Sci...302.1208G.