Biology:Regulator of cell cycle RGCC
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Regulator of cell cycle RGCC (RGCC) also known as response gene to complement 32 protein (RGC-32) is a protein that in humans is encoded by the RGCC gene.[1][2][3]
Function
This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression.[3]
References
- ↑ "RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest". Oncogene 26 (8): 1110–21. Feb 2007. doi:10.1038/sj.onc.1210148. PMID 17146433.
- ↑ "RGC-32 mediates transforming growth factor-beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells". J Biol Chem 284 (14): 9426–32. Mar 2009. doi:10.1074/jbc.M900039200. PMID 19158077.
- ↑ 3.0 3.1 "Entrez Gene: RGC32 response gene to complement 32". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28984.
Further reading
- "The role of c5b-9 terminal complement complex in activation of the cell cycle and transcription.". Immunol. Res. 31 (1): 37–46. 2005. doi:10.1385/IR:31:1:37. PMID 15591621.
- "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Molecular cloning and characterization of RGC-32, a novel gene induced by complement activation in oligodendrocytes.". J. Biol. Chem. 273 (41): 26977–81. 1998. doi:10.1074/jbc.273.41.26977. PMID 9756947.
- "RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase.". J. Biol. Chem. 277 (1): 502–8. 2002. doi:10.1074/jbc.M109354200. PMID 11687586.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Overexpression of RGC-32 in colon cancer and other tumors.". Exp. Mol. Pathol. 78 (2): 116–22. 2005. doi:10.1016/j.yexmp.2004.11.001. PMID 15713436.
- "Distinct gene expression patterns of peripheral blood cells in hyper-IgE syndrome.". Clin. Exp. Immunol. 140 (3): 524–31. 2005. doi:10.1111/j.1365-2249.2005.02805.x. PMID 15932515.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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