Biology:RivX sRNA
| RivX | |
|---|---|
 Predicted secondary structure of RivX sRNA | |
| Identifiers | |
| Symbol | RivX |
| Other data | |
| RNA type | sRNA |
| Domain(s) | Streptococcus pyogenes |
| PDB structures | PDBe |
RivX sRNA is a non-coding RNA molecule involved in the interface between two key regulators of virulence in the human pathogen Streptococcus pyogenes (Group A Streptoccus, also known as GAS): the CovR/S system[1] and Mga regulator.[2] This RNA, along with its downstream protein-coding gene RivR, are the first discovered links between these two important regulation networks.[2] An extra protein linking the two pathways, TrxR, was described a year later.[3] The adjoining of these two pathways could allow a consistently high virulence of S. pyogenes despite a variety of environmental conditions.[2]
RivX is thought to be co-transcribed with RivR mRNA before post-transcriptional processing releases the sRNA. It was found to be a non-coding transcript through site-directed mutagenesis experimentation.[2]
In total, the GAS genome is now predicted to encode 75 total sRNAs, a number approximately equal to the number of transcription factors encoded by the genome, which shows the importance of RNA regulation in GAS.[4]
References
- ↑ "The two faces of Janus: virulence gene regulation by CovR/S in group A streptococci". Molecular Microbiology 64 (1): 34–41. April 2007. doi:10.1111/j.1365-2958.2007.05649.x. PMID 17376070.
- ↑ 2.0 2.1 2.2 2.3 "RivR and the small RNA RivX: the missing links between the CovR regulatory cascade and the Mga regulon". Molecular Microbiology 66 (6): 1506–1522. December 2007. doi:10.1111/j.1365-2958.2007.06015.x. PMID 18005100.
- ↑ "TrxR, a new CovR-repressed response regulator that activates the Mga virulence regulon in group A Streptococcus". Infection and Immunity 76 (10): 4659–4668. October 2008. doi:10.1128/IAI.00597-08. PMID 18678666.
- ↑ "A genome-wide analysis of small regulatory RNAs in the human pathogen group A Streptococcus". PLOS ONE 4 (11): e7668. November 2009. doi:10.1371/journal.pone.0007668. PMID 19888332. Bibcode: 2009PLoSO...4.7668P.
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