Biology:S100A13
 Generic protein structure example |
S100 calcium-binding protein A13 (S100A13) is a protein that in humans is encoded by the S100A13 gene.[1][2]
Function
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.[2]
Interactions
S100A13 has been shown to interact with SYT1[3][4] and FGF1.[3][4]
Pathology
Up-regulation of S100A13 was detected in cystic papillary thyroid carcinoma[5] and association of S100A13 expression and chemotherapy resistance was shown in proteomics study of melanoma.[6]
References
- ↑ "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium 20 (6): 459–64. Dec 1996. doi:10.1016/S0143-4160(96)90087-1. PMID 8985590.
- ↑ 2.0 2.1 "Entrez Gene: S100A13 S100 calcium binding protein A13". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6284.
- ↑ 3.0 3.1 "S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro". The Journal of Biological Chemistry 273 (35): 22224–31. Aug 1998. doi:10.1074/jbc.273.35.22224. PMID 9712836.
- ↑ 4.0 4.1 "Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress". The Journal of Biological Chemistry 276 (27): 25549–57. Jul 2001. doi:10.1074/jbc.M102925200. PMID 11432880.
- ↑ "Differential protein expression profiles of cyst fluid from papillary thyroid carcinoma and benign thyroid lesions". PLOS ONE 10 (5): e0126472. May 2015. doi:10.1371/journal.pone.0126472. PMID 25978681. Bibcode: 2015PLoSO..1026472D.
- ↑ "Proteomics analysis of melanoma metastases: association between S100A13 expression and chemotherapy resistance". British Journal of Cancer 110 (10): 2489–2495. 2014. doi:10.1038/bjc.2014.169. PMID 24722184.
Further reading
- "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature 377 (6547 Suppl): 3–174. Sep 1995. PMID 7566098. http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf.
- "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics 25 (3): 638–43. Feb 1995. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
- "Characterization of the human and mouse cDNAs coding for S100A13, a new member of the S100 protein family". Biochemical and Biophysical Research Communications 227 (2): 594–9. Oct 1996. doi:10.1006/bbrc.1996.1551. PMID 8878558.
- "S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro". The Journal of Biological Chemistry 273 (35): 22224–31. Aug 1998. doi:10.1074/jbc.273.35.22224. PMID 9712836.
- "S100A13. Biochemical characterization and subcellular localization in different cell lines". The Journal of Biological Chemistry 275 (12): 8686–94. Mar 2000. doi:10.1074/jbc.275.12.8686. PMID 10722710.
- "Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress". The Journal of Biological Chemistry 276 (27): 25549–57. Jul 2001. doi:10.1074/jbc.M102925200. PMID 11432880.
- "S100A13 and S100A6 exhibit distinct translocation pathways in endothelial cells". Journal of Cell Science 115 (Pt 15): 3149–58. Aug 2002. doi:10.1242/jcs.115.15.3149. PMID 12118070.
- "The intracellular translocation of the components of the fibroblast growth factor 1 release complex precedes their assembly prior to export". The Journal of Cell Biology 158 (2): 201–8. Jul 2002. doi:10.1083/jcb.200203084. PMID 12135982.
- "Differential expression of S100 proteins in the developing human hippocampus and temporal cortex". Microscopy Research and Technique 60 (6): 600–13. Apr 2003. doi:10.1002/jemt.10302. PMID 12645008.
- "S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells". Journal of Cell Science 116 (Pt 13): 2687–96. Jul 2003. doi:10.1242/jcs.00471. PMID 12746488. https://flore.unifi.it/bitstream/2158/224684/1/JC%20Science%202003.pdf.
- "S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells". Biochemical and Biophysical Research Communications 316 (3): 949–59. Apr 2004. doi:10.1016/j.bbrc.2004.02.135. PMID 15033494.
- "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. Jan 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
- "Endoglin (cd105) and S100A13 as markers of active angiogenesis in endometriosis". Reproductive Biology 5 (1): 51–67. Mar 2005. PMID 15821778.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Transcriptome analysis of human gastric cancer". Mammalian Genome 16 (12): 942–54. Dec 2005. doi:10.1007/s00335-005-0075-2. PMID 16341674.
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