Biology:S100A3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

S100 calcium-binding protein A3 (S100A3) is a protein that in humans is encoded by the S100A3 gene.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown.

Further reading

• "The S100 family of EF-hand calcium-binding proteins: functions and pathology.". Trends Biochem. Sci. 21 (4): 134–40. 1996. doi:10.1016/S0968-0004(96)80167-8. PMID 8701470. 
• "Purification and cation binding properties of the recombinant human S100 calcium-binding protein A3, an EF-hand motif protein with high affinity for zinc.". J. Biol. Chem. 270 (36): 21056–61. 1995. doi:10.1074/jbc.270.36.21056. PMID 7673133. 
• "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family.". Genomics 25 (3): 638–43. 1995. doi:10.1016/0888-7543(95)80005-7. PMID 7759097. 
• "Highly-expressed S100A3, a calcium-binding protein, in human hair cuticle.". Biochim. Biophys. Acta 1312 (2): 94–8. 1996. doi:10.1016/0167-4889(96)00023-7. PMID 8672544. 
• "Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesions.". Br. J. Dermatol. 137 (1): 39–43. 1997. doi:10.1111/j.1365-2133.1997.tb03698.x. PMID 9274623. 
• "A model for target protein binding to calcium-activated S100 dimers.". FEBS Lett. 421 (3): 175–9. 1998. doi:10.1016/S0014-5793(97)01535-4. PMID 9468301. 
• "Clustered organization of S100 genes in human and mouse.". Biochim. Biophys. Acta 1448 (2): 254–63. 1999. doi:10.1016/S0167-4889(98)00137-2. PMID 9920416. 
• "Probing the structure of the human Ca2+- and Zn2+-binding protein S100A3: spectroscopic investigations of its transition metal ion complexes, and three-dimensional structural model.". Biochim. Biophys. Acta 1448 (2): 264–76. 1999. doi:10.1016/S0167-4889(98)00138-4. PMID 9920417. 
• "S100 proteins in Corpora amylacea from normal human brain.". Brain Res. 867 (1–2): 280–8. 2000. doi:10.1016/S0006-8993(00)02393-3. PMID 10837826. 
• "The crystal structure of metal-free human EF-hand protein S100A3 at 1.7-A resolution". J. Biol. Chem. 277 (36): 33092–8. 2002. doi:10.1074/jbc.M200574200. PMID 12045193. 
• "Metal-free MIRAS phasing: structure of apo-S100A3". Acta Crystallogr. D 58 (Pt 8): 1255–61. 2003. doi:10.1107/S0907444902008430. PMID 12136135. 
• "Characterization of the cysteine-rich calcium-binding S100A3 protein from human hair cuticles". Biochem. Biophys. Res. Commun. 299 (5): 857–62. 2003. doi:10.1016/S0006-291X(02)02744-4. PMID 12470658. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G. 
• "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.