Biology:SAE1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
SUMO-activating enzyme subunit 1 is a protein that in humans is encoded by the SAE1 gene.[1][2][3][4]
Interactions
SAE1 has been shown to interact with SAE2, the protein product of the gene UBA2.[1][3][5][6]
References
- ↑ 1.0 1.1 "Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1". J. Biol. Chem. 274 (15): 10618–24. May 1999. doi:10.1074/jbc.274.15.10618. PMID 10187858.
- ↑ "In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2". Biochem. Biophys. Res. Commun. 254 (3): 693–8. Mar 1999. doi:10.1006/bbrc.1998.9995. PMID 9920803.
- ↑ 3.0 3.1 "Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex". FEBS Lett. 448 (1): 185–9. Jun 1999. doi:10.1016/S0014-5793(99)00367-1. PMID 10217437.
- ↑ "Entrez Gene: SAE1 SUMO1 activating enzyme subunit 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10055.
- ↑ "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- ↑ "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
Further reading
- "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. 2000. doi:10.1101/gr.140200. PMID 11042152.
- "Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9". J. Biol. Chem. 276 (38): 35368–74. 2001. doi:10.1074/jbc.M104214200. PMID 11451954.
- "Expression and regulation of the mammalian SUMO-1 E1 enzyme". FASEB J. 15 (10): 1825–7. 2001. doi:10.1096/fj.00-0818fje. PMID 11481243.
- "Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation". Biochemistry 42 (33): 9959–69. 2003. doi:10.1021/bi0345283. PMID 12924945.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9". Mol. Endocrinol. 18 (10): 2451–62. 2004. doi:10.1210/me.2004-0173. PMID 15192080.
- "SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1". J. Cell Biol. 165 (6): 767–73. 2004. doi:10.1083/jcb.200310136. PMID 15210726.
- "Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53". FEBS Lett. 573 (1–3): 15–8. 2004. doi:10.1016/j.febslet.2004.07.059. PMID 15327968.
- "A mechanism for inhibiting the SUMO pathway". Mol. Cell 16 (4): 549–61. 2004. doi:10.1016/j.molcel.2004.11.007. PMID 15546615.
- "Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1". EMBO J. 24 (3): 439–51. 2005. doi:10.1038/sj.emboj.7600552. PMID 15660128.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "SUMO-1 controls the protein stability and the biological function of phosducin". J. Biol. Chem. 281 (13): 8357–64. 2006. doi:10.1074/jbc.M513703200. PMID 16421094.
- "A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers". Arch. Biochem. Biophys. 453 (1): 70–4. 2006. doi:10.1016/j.abb.2006.03.002. PMID 16620772. https://zenodo.org/record/1258674.
- "Ubc9 interacts with SOX4 and represses its transcriptional activity". Biochem. Biophys. Res. Commun. 344 (3): 727–34. 2006. doi:10.1016/j.bbrc.2006.03.194. PMID 16631117.
External links
- SAE1 human gene location in the UCSC Genome Browser.
- SAE1 human gene details in the UCSC Genome Browser.
PDB gallery | |
|---|---|
|
 |
