Biology:SAP18
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Short description: Protein-coding gene in the species Homo sapiens
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Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the SAP18 gene.[1][2]
Function
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Multisubunit complexes catalyze histone acetylation and deacetylation. The protein encoded by this gene is a histone deacetylase complex component, including SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.[2] Additionally, SAP18s splice variants are implicated in apoptotic cycles.[3]
Interactions
SAP18 has been shown to interact with
References
- ↑ "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell 89 (3): 357–64. May 1997. doi:10.1016/S0092-8674(00)80216-0. PMID 9150135.
- ↑ 2.0 2.1 "Entrez Gene: SAP18 Sin3A-associated protein, 18kDa". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10284.
- ↑ "Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators". Molecular and Cellular Biology 32 (5): 954–67. March 2012. doi:10.1128/MCB.06130-11. PMID 22203037.
- ↑ "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". Journal of Biochemistry 131 (3): 307–11. March 2002. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158.
- ↑ "Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex". Proceedings of the National Academy of Sciences of the United States of America 99 (8): 5442–7. April 2002. doi:10.1073/pnas.082096999. PMID 11960000. Bibcode: 2002PNAS...99.5442C.
- ↑ "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
Further reading
- "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". The EMBO Journal 18 (11): 3090–100. June 1999. doi:10.1093/emboj/18.11.3090. PMID 10357820.
- "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". Journal of Biochemistry 131 (3): 307–11. March 2002. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158.
- "Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex". Proceedings of the National Academy of Sciences of the United States of America 99 (8): 5442–7. April 2002. doi:10.1073/pnas.082096999. PMID 11960000. Bibcode: 2002PNAS...99.5442C.
- "The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins". The Biochemical Journal 378 (Pt 2): 353–62. March 2004. doi:10.1042/BJ20030786. PMID 14611647.
- "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. January 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
External links
- SAP18 human gene location in the UCSC Genome Browser.
- SAP18 human gene details in the UCSC Genome Browser.
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