Biology:SCG3
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Secretogranin III, also known as SCG3, is a protein which in humans is encoded by the SCG3 gene.[1][2]
Function
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown.[2]
References
- ↑ "Cloning and characterization of a novel human secretory protein: secretogranin III". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica 34 (4): 411–7. July 2002. PMID 12098761. http://www.abbs.info/fulltxt/eng/34040411.htm.
- ↑ 2.0 2.1 "Entrez Gene: SCG3 secretogranin III". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29106.
Further reading
- "The granin (chromogranin/secretogranin) family". Trends in Biochemical Sciences 16 (1): 27–30. January 1991. doi:10.1016/0968-0004(91)90012-K. PMID 2053134.
- "The granin family--its role in sorting and secretory granule formation". Cell Structure and Function 20 (6): 415–20. December 1995. doi:10.1247/csf.20.415. PMID 8825061.
- "Primary structure of mouse secretogranin III and its absence from deficient mice". Journal of Molecular Neuroscience 4 (4): 225–33. 1994. doi:10.1007/BF02821554. PMID 7917832.
- "Secretogranin III is a sulfated protein undergoing proteolytic processing in the regulated secretory pathway". The Journal of Biological Chemistry 271 (30): 17755–60. July 1996. doi:10.1074/jbc.271.30.17755. PMID 8663421.
- "Cloning and characterization of a novel human secretory protein: secretogranin III". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica 34 (4): 411–7. July 2002. PMID 12098761.
- "Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells". Molecular Biology of the Cell 13 (10): 3388–99. October 2002. doi:10.1091/mbc.02-03-0040. PMID 12388744.
- "Immunocytochemical localization of secretogranin III in the anterior lobe of male rat pituitary glands". The Journal of Histochemistry and Cytochemistry 51 (2): 227–38. February 2003. doi:10.1177/002215540305100211. PMID 12533531.
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research 13 (10): 2265–70. October 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A". The Journal of Biological Chemistry 279 (5): 3627–34. January 2004. doi:10.1074/jbc.M310104200. PMID 14597614.
- "Immunocytochemical localization of secretogranin III in the endocrine pancreas of male rats". Archives of Histology and Cytology 67 (1): 57–64. March 2004. doi:10.1679/aohc.67.57. PMID 15125023.
- "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research 12 (2): 117–26. 2007. doi:10.1093/dnares/12.2.117. PMID 16303743.
- "Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity". The Journal of Clinical Endocrinology and Metabolism 92 (3): 1145–54. March 2007. doi:10.1210/jc.2006-1808. PMID 17200173.
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