Biology:SEDLP
From HandWiki
Short description: Pseudogene in the species Homo sapiens
 Generic protein structure example |
Trafficking protein particle complex subunit 2 is a protein that in humans is encoded by the TRAPPC2P1 gene.[1]
This gene has been described as a transcribed retropseudogene (or retro-xaptonuon) based on its structure which lacks most of the introns of SEDL and the detection of transcripts from this locus. Most retropseudogenes are thought to not express protein products. A protein product could potentially be encoded by this retropseudogene that would be identical to the protein product of the SEDL gene. However, it remains unclear whether this gene encodes a protein product or is a transcribed retropseudogene.[1]
References
Further reading
- Sacher M (2003). "Membrane traffic fuses with cartilage development.". FEBS Lett. 550 (1–3): 1–4. doi:10.1016/S0014-5793(03)00854-8. PMID 12935876.
- "Gene structure and expression study of the SEDL gene for spondyloepiphyseal dysplasia tarda". Genomics 69 (2): 242–51. 2001. doi:10.1006/geno.2000.6326. PMID 11031107.
- "A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1". Mol. Cell. Biol. 21 (2): 655–62. 2001. doi:10.1128/MCB.21.2.655-662.2001. PMID 11134351.
- "The sequence of the human genome". Science 291 (5507): 1304–51. 2001. doi:10.1126/science.1058040. PMID 11181995. Bibcode: 2001Sci...291.1304V.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Modulation of human luteinizing hormone beta gene transcription by MIP-2A". J. Biol. Chem. 278 (26): 24033–8. 2003. doi:10.1074/jbc.M211982200. PMID 12700240.
- "Spondyloepiphyseal dysplasia tarda (SEDL, MIM #313400)". Eur. J. Hum. Genet. 11 (9): 639–42. 2004. doi:10.1038/sj.ejhg.5201025. PMID 12939648.
- "Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not". Gene 320: 137–44. 2004. doi:10.1016/S0378-1119(03)00819-9. PMID 14597397.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
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