Biology:SEMA4A
From HandWiki
 Generic protein structure example |
Semaphorin-4A is a protein that in humans is encoded by the SEMA4A gene.[1][2]
Function
SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.[supplied by OMIM][2]
Clinical significance
A germline variant in SEMA4A (V78M) has been demonstrated to confer risk for colorectal cancer type X.[3]
References
- ↑ "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron 14 (5): 941–8. Jun 1995. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
- ↑ 2.0 2.1 "Entrez Gene: SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64218.
- ↑ "Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X.". Nature Communications 5: 5191. Oct 2014. doi:10.1038/ncomms6191. PMID 25307848. Bibcode: 2014NatCo...5.5191S.
Further reading
- "Semaphorins in interactions between T cells and antigen-presenting cells.". Nat. Rev. Immunol. 3 (2): 159–67. 2003. doi:10.1038/nri1003. PMID 12563299.
- "Immune semaphorins: a new area of semaphorin research.". J. Cell Sci. 116 (Pt 17): 3463–70. 2004. doi:10.1242/jcs.00674. PMID 12893810.
- "Structure and function of the immune semaphorin CD100/SEMA4D.". Crit. Rev. Immunol. 23 (1–2): 65–81. 2004. doi:10.1615/CritRevImmunol.v23.i12.40. PMID 12906260.
- "Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2.". Nature 419 (6907): 629–33. 2002. doi:10.1038/nature01037. PMID 12374982. Bibcode: 2002Natur.419..629K.
- "Identification of novel mutations in the SEMA4A gene associated with retinal degenerative diseases.". J. Med. Genet. 43 (4): 378–81. 2006. doi:10.1136/jmg.2005.035055. PMID 16199541.
- "Biology and function of neuroimmune semaphorins 4A and 4D". Immunol. Res. 50 (1): 10–21. 2011. doi:10.1007/s12026-010-8201-y. PMID 21203905.
- "Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor". BMC Immunol. 12: 30. 2011. doi:10.1186/1471-2172-12-30. PMID 21595947.
- "Neuroimmune semaphorin 4A downregulates the severity of allergic response". Mucosal Immunol. 5 (4): 409–19. 2012. doi:10.1038/mi.2012.18. PMID 22472774.
- "Neuroimmune semaphorin 4A as a drug and drug target for asthma". Int. Immunopharmacol. 17 (3): 568–75. 2013. doi:10.1016/j.intimp.2013.08.005. PMID 23994348.
- "Semaphorin 4A as novel regulator and promising therapeutic target in rheumatoid arthritis". Arthritis Res. Ther. 17: 313. 2015. doi:10.1186/s13075-015-0846-4. PMID 26542940.
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