Biology:SEPX1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Methionine-R-sulfoxide reductase B1 is an enzyme that in humans is encoded by the SEPX1 gene.[1][2]
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase B (MsrB) family, and it is expressed in a variety of adult and fetal tissues.[2]
See also
- MSRA (gene)
- MSRB2
- Methionine oxidation
References
- ↑ "Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif". J Biol Chem 274 (53): 38147–54. Feb 2000. doi:10.1074/jbc.274.53.38147. PMID 10608886.
- ↑ 2.0 2.1 "Entrez Gene: SEPX1 selenoprotein X, 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51734.
Further reading
- "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- "New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements.". J. Biol. Chem. 274 (48): 33888–97. 1999. doi:10.1074/jbc.274.48.33888. PMID 10567350. http://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1068&context=biochemgladyshev.
- "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. 2001. doi:10.1101/gr.140200. PMID 11042152.
- "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.". Hum. Mol. Genet. 10 (4): 339–52. 2001. doi:10.1093/hmg/10.4.339. PMID 11157797.
- "Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity.". Biochem. Biophys. Res. Commun. 290 (1): 62–5. 2002. doi:10.1006/bbrc.2001.6171. PMID 11779133. https://zenodo.org/record/1229532.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases.". Mol. Biol. Cell 15 (3): 1055–64. 2004. doi:10.1091/mbc.E03-08-0629. PMID 14699060.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
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