Biology:SERPINB1
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Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. It is a member of the clade B serpins or ov-serpins (ovalbumin related serpins) founded by ovalbumin.[1][2][3]
MNEI (monocyte/neutrophil elastase inhibitor) is the mouse orthologue of human SerpinB1.[3]
Function
SerpinB1 is a cytoplasmic serine protease inhibitor of polymorphonuclear neutrophils. Among other serine proteases, it specifically inhibits neutrophil elastase, PR3 and cathepsin G, all found in neutrophil granules, by a suicide inhibition mechanism. SerpinB1 was found to reduce tissue damage caused by the mentioned proteases during inflammation and has a role in neutrophil homeostasis in mice. In various infection models (e.g. pneumonia) correlation of SerpinB1 absence and lack of microbial clearance have been shown. Different knockout strains serve as model to investigate the role of SerpinB1 in vivo.[4][5][6]
See also
References
- ↑ "Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor". Proc Natl Acad Sci U S A 89 (12): 5635–9. Jul 1992. doi:10.1073/pnas.89.12.5635. PMID 1376927.
- ↑ "Entrez Gene: SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1992.
- ↑ 3.0 3.1 "The ovalbumin serpins revisited: perspective from the chicken genome of clade B serpin evolution in vertebrates". Proc. Natl. Acad. Sci. U.S.A. 102 (32): 11367–72. August 2005. doi:10.1073/pnas.0502934102. PMID 16055559.
- ↑ "Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection". J. Infect. Dis. 204 (4): 592–600. August 2011. doi:10.1093/infdis/jir352. PMID 21791661.
- ↑ "SerpinB1 protects the mature neutrophil reserve in the bone marrow". J. Leukoc. Biol. 90 (1): 21–9. July 2011. doi:10.1189/jlb.0810461. PMID 21248149.
- ↑ "The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection". J. Exp. Med. 204 (8): 1901–9. August 2007. doi:10.1084/jem.20070494. PMID 17664292.
Further reading
- "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.". Electrophoresis 13 (12): 960–9. 1993. doi:10.1002/elps.11501301199. PMID 1286667.
- "A serpin from human tumor cells with direct lymphoid immunomodulatory activity: mitogenic stimulation of human tumor-infiltrating lymphocytes.". Biochim. Biophys. Acta 1269 (1): 41–50. 1995. doi:10.1016/0167-4889(95)00113-7. PMID 7578269.
- "Inhibitory properties of recombinant human monocyte/neutrophil elastase inhibitor.". Am. J. Respir. Cell Mol. Biol. 13 (3): 314–22. 1995. doi:10.1165/ajrcmb.13.3.7654387. PMID 7654387.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Characterization and chromosomal localization of ELANH2, the gene encoding human monocyte/neutrophil elastase inhibitor.". Genomics 28 (2): 235–40. 1996. doi:10.1006/geno.1995.1136. PMID 8530031.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Structure and sequence of human M/NEI (monocyte/neutrophil elastase inhibitor), an Ov-serpin family gene.". Gene 213 (1–2): 179–87. 1998. doi:10.1016/S0378-1119(98)00189-9. PMID 9630619.
- "A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes.". Cytogenet. Cell Genet. 82 (3–4): 273–7. 1999. doi:10.1159/000015118. PMID 9858835.
- "Mutations on the hinge region of leukocyte elastase inhibitor determine the loss of inhibitory function.". Biochem. Biophys. Res. Commun. 274 (3): 841–4. 2000. doi:10.1006/bbrc.2000.3191. PMID 10924364.
- "The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites.". Biochemistry 40 (51): 15762–70. 2002. doi:10.1021/bi0113925. PMID 11747453.
- "Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates.". J. Biol. Chem. 277 (42): 39074–81. 2002. doi:10.1074/jbc.M202918200. PMID 12114510.
- "Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1).". J. Biol. Chem. 277 (44): 42028–33. 2003. doi:10.1074/jbc.M207080200. PMID 12189154.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. 2004. doi:10.1038/nbt810. PMID 12665801.
- "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. 2003. doi:10.1038/nature02055. PMID 14574404.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry.". J. Proteome Res. 4 (3): 931–40. 2005. doi:10.1021/pr050024a. PMID 15952740.
External links
- The MEROPS online database for peptidases and their inhibitors: I04.006
- SERPINB1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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