Biology:SESN1
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Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.[1][2][3]
See also
References
- ↑ "Entrez Gene: sestrin 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27244.
- ↑ "Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes". Proceedings of the National Academy of Sciences of the United States of America 91 (22): 10640–4. October 1994. doi:10.1073/pnas.91.22.10640. PMID 7938006. Bibcode: 1994PNAS...9110640B.
- ↑ "PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes". Oncogene 18 (1): 127–37. January 1999. doi:10.1038/sj.onc.1202274. PMID 9926927.
Further reading
- "Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD". Science 304 (5670): 596–600. April 2004. doi:10.1126/science.1095569. PMID 15105503. Bibcode: 2004Sci...304..596B.
- "PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse". Human Genetics 112 (5–6): 573–80. May 2003. doi:10.1007/s00439-003-0917-5. PMID 12607115.
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