Biology:SHC3
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
SHC-transforming protein 3 is a protein that in humans is encoded by the SHC3 gene.[1][2]
Interactions
SHC3 has been shown to interact with RICS[3] and TrkB.[4][5]
References
- ↑ "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway". Oncogene 13 (6): 1111–21. September 1996. PMID 8808684.
- ↑ "Entrez Gene: SHC3 SHC (Src homology 2 domain containing) transforming protein 3". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=53358.
- ↑ "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Molecular and Cellular Biology 22 (24): 8721–34. December 2002. doi:10.1128/MCB.22.24.8721-8734.2002. PMID 12446789.
- ↑ "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". The Journal of Biological Chemistry 273 (12): 6960–7. March 1998. doi:10.1074/jbc.273.12.6960. PMID 9507002.
- ↑ "Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor". Biochemical and Biophysical Research Communications 294 (5): 1087–92. June 2002. doi:10.1016/S0006-291X(02)00606-X. PMID 12074588.
Further reading
- "A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain". Proceedings of the National Academy of Sciences of the United States of America 93 (7): 2729–34. April 1996. doi:10.1073/pnas.93.7.2729. PMID 8610109. Bibcode: 1996PNAS...93.2729O.
- "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions". Oncogene 13 (3): 633–41. August 1996. PMID 8760305.
- "Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum". Biochemical and Biophysical Research Communications 238 (3): 800–5. September 1997. doi:10.1006/bbrc.1997.7393. PMID 9325171.
- "Signal transduction in human hematopoietic cells by vascular endothelial growth factor related protein, a novel ligand for the FLT4 receptor". Blood 90 (9): 3507–15. November 1997. doi:10.1182/blood.V90.9.3507. PMID 9345034.
- "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". The Journal of Biological Chemistry 273 (12): 6960–7. March 1998. doi:10.1074/jbc.273.12.6960. PMID 9507002.
- "Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase". The Journal of Biological Chemistry 277 (15): 13268–80. April 2002. doi:10.1074/jbc.M108898200. PMID 11812778.
- "Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc". The Journal of Biological Chemistry 277 (19): 16798–804. May 2002. doi:10.1074/jbc.M110286200. PMID 11877420.
- "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases". The Journal of Biological Chemistry 277 (29): 26046–56. July 2002. doi:10.1074/jbc.M111659200. PMID 12006576.
- "Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines". Oncogene 21 (38): 5823–34. August 2002. doi:10.1038/sj.onc.1205735. PMID 12185581.
- "The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway". Molecular and Cellular Biology 22 (20): 7351–63. October 2002. doi:10.1128/MCB.22.20.7351-7363.2002. PMID 12242309.
- "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Molecular and Cellular Biology 22 (24): 8721–34. December 2002. doi:10.1128/MCB.22.24.8721-8734.2002. PMID 12446789.
- "Domain-specific function of ShcC docking protein in neuroblastoma cells". Oncogene 24 (19): 3206–15. April 2005. doi:10.1038/sj.onc.1208523. PMID 15735675.
- "Shc3 affects human high-grade astrocytomas survival". Oncogene 24 (33): 5198–206. August 2005. doi:10.1038/sj.onc.1208708. PMID 15870690.
- "RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors". Oncogene 24 (41): 6303–13. September 2005. doi:10.1038/sj.onc.1208776. PMID 15940252.
- "HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway". Molecular Biology of the Cell 17 (4): 1985–94. April 2006. doi:10.1091/mbc.E05-08-0717. PMID 16436505.
- "Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence". Molecular Psychiatry 12 (5): 462–73. May 2007. doi:10.1038/sj.mp.4001933. PMID 17179996.
 |  |
