Biology:SLC9B2
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 Generic protein structure example |
Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 is a protein that in humans is encoded by the SLC9B2 gene.[1]
Function
Sodium–hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux.[2]
References
- ↑ "Entrez Gene: Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2". https://www.ncbi.nlm.nih.gov/gene/133308.
- ↑ "A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension". Proceedings of the National Academy of Sciences of the United States of America 104 (47): 18677–81. November 2007. doi:10.1073/pnas.0707120104. PMID 18000046.
Further reading
- "Unconventional chemiosmotic coupling of NHA2, a mammalian Na+/H+ antiporter, to a plasma membrane H+ gradient". The Journal of Biological Chemistry 287 (43): 36239–50. October 2012. doi:10.1074/jbc.M112.403550. PMID 22948142.
- "Proteomic profile of osteoclast membrane proteins: identification of Na+/H+ exchanger domain containing 2 and its role in osteoclast fusion". Proteomics 8 (13): 2625–39. July 2008. doi:10.1002/pmic.200701192. PMID 18600791.
- "Mutational analysis of NHAoc/NHA2 in Saccharomyces cerevisiae". Biochimica et Biophysica Acta (BBA) - General Subjects 1800 (12): 1241–7. December 2010. doi:10.1016/j.bbagen.2010.08.001. PMID 20713131.
- "Characterization of the sodium/hydrogen exchanger NHA2". Journal of the American Society of Nephrology 19 (8): 1547–56. August 2008. doi:10.1681/ASN.2007111245. PMID 18508966.
- "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Human Molecular Genetics 19 (12): 2497–506. June 2010. doi:10.1093/hmg/ddq112. PMID 20332099.
- "NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts". Bone 42 (1): 180–92. January 2008. doi:10.1016/j.bone.2007.09.046. PMID 17988971.
- "Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension". Journal of Molecular Biology 396 (5): 1181–96. March 2010. doi:10.1016/j.jmb.2009.12.055. PMID 20053353.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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